Drug Information

Drug General Information
Drug ID
D0YC1I
Former ID
DNC001251
Drug Name
S-(-)-Lisuride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535914]
Structure
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2D MOL

3D MOL
Formula
C20H26N4O
Canonical SMILES
CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
InChI
1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18-/m1/s1
InChIKey
BKRGVLQUQGGVSM-RDTXWAMCSA-N
CAS Number
CAS 140387-89-9
PubChem Compound ID
11957615
PubChem Substance ID
17405342, 23919056, 26756522, 36454879, 47646559, 47720611, 47795044, 49846681, 53777887, 57377655, 76836309, 85788551, 92304081, 124749994, 134339633, 175267560, 242326804
SuperDrug ATC ID
G02CB02
SuperDrug CAS ID
cas=018016803
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [535914]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 5359148R-lisuride is a potent stereospecific histamine H1-receptor partial agonist. Mol Pharmacol. 2004 Mar;65(3):538-49.
Ref 5359148R-lisuride is a potent stereospecific histamine H1-receptor partial agonist. Mol Pharmacol. 2004 Mar;65(3):538-49.

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