TTD | Drug: D0YK9D

Drug General Information
Drug ID	D0YK9D
Former ID	DIB019123
Drug Name	CHIR-99021
Synonyms	CHIR99021; CHIR 99021; CT-99021; CT99021
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525550]
Structure		Download 2D MOL 3D MOL
Formula	C22H18Cl2N8
InChI	InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
InChIKey	AQGNHMOJWBZFQQ-UHFFFAOYSA-N
PubChem Compound ID	9956119
PubChem Substance ID	14931758, 46052726, 77619611, 84982162, 90306847, 99222801, 99437061, 103566476, 103905640, 123105098, 124757128, 125163932, 125329941, 125333824, 126731259, 127443675, 131480740, 134216516, 135697745, 135727435, 136157396, 136367374, 136367993, 136920307, 137275880, 142261085, 144115822, 152043829, 152186750, 152258107, 152344405, 160646946, 162011409, 162037525, 162202606, 162211052, 162823708, 163685877, 163726080, 163780442, 163907957, 164042070, 164150165, 172087016, 172131585, 172649829, 174007034, 174528565, 180060723, 186006539
Target and Pathway
Target(s)	Cell division control protein 2 homolog	Target Info	Inhibitor	[526553]
	Glycogen synthase kinase-3 beta	Target Info	Inhibitor	[526553]
	mRNA of human glycogen synthase kinase 3 alpha	Target Info	Inhibitor	[526553]
	Mitogen-activated protein kinase 1	Target Info	Inhibitor	[526553]
KEGG Pathway	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Gap junction
	Progesterone-mediated oocyte maturation
	Herpes simplex infection
	Epstein-Barr virus infection
	Viral carcinogenesishsa04012:ErbB signaling pathway
	Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Wnt signaling pathway
	Hedgehog signaling pathway
	Axon guidance
	Hippo signaling pathway
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Dopaminergic synapse
	Insulin signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Alzheimer's disease
	Hepatitis C
	Measles
	Influenza A
	HTLV-I infection
	Pathways in cancer
	Colorectal cancer
	Endometrial cancer
	Prostate cancer
	Basal cell carcinomahsa04062:Chemokine signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)hsa04010:MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	mTOR signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Dorso-ventral axis formation
	TGF-beta signaling pathway
	VEGF signaling pathway
	Osteoclast differentiation
	Adherens junction
	Platelet activation
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	Natural killer cell mediated cytotoxicity
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	TNF signaling pathway
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Prion diseases
Alcoholism
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Pancreatic cancer
Glioma
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
NetPath Pathway	RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Angiogenesis
	Cadherin signaling pathway
	Hedgehog signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Interleukin signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	Wnt signaling pathway
	Ras Pathway
	CCKR signaling map STP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Ras PathwayP00003:Alzheimer disease-amyloid secretase pathway
	Apoptosis signaling pathway
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Interferon-gamma signaling pathway
	Parkinson disease
	TGF-beta signaling pathway
	T cell activation
	VEGF signaling pathway
	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
	CCKR signaling map ST
Pathway Interaction Database	p73 transcription factor network
	E2F transcription factor network
	PLK1 signaling events
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Retinoic acid receptors-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
	Degradation of beta catenin
	Reelin signaling pathway
	Presenilin action in Notch and Wnt signaling
	Integrin-linked kinase signaling
	CDC42 signaling events
	LKB1 signaling events
	Canonical Wnt signaling pathway
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	C-MYC pathway
	Regulation of Androgen receptor activity
	BMP receptor signaling
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Validated transcriptional targets of deltaNp63 isoforms
	Aurora A signaling
	Insulin-mediated glucose transport
	Class I PI3K signaling events mediated by Akt
	p53 pathway
	Trk receptor signaling mediated by PI3K and PLC-gammabetacatenin_deg_pathway:Degradation of beta catenin
	Class I PI3K signaling events mediated by Aktfcer1pathway:Fc-epsilon receptor I signaling in mast cells
	Endothelins
	BCR signaling pathway
	Signaling events mediated by PRL
	ErbB4 signaling events
	GMCSF-mediated signaling events
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	S1P3 pathway
	EPHB forward signaling
	Osteopontin-mediated events
	S1P4 pathway
	TRAIL signaling pathway
	Signaling events regulated by Ret tyrosine kinase
	Angiopoietin receptor Tie2-mediated signaling
	S1P1 pathway
	Regulation of Telomerase
	Netrin-mediated signaling events
	Arf6 downstream pathway
	mTOR signaling pathway
	Class IB PI3K non-lipid kinase events
	IL2-mediated signaling events
	EGF receptor (ErbB1) signaling pathway
	Ras signaling in the CD4+ TCR pathway
	Ceramide signaling pathway
	Integrins in angiogenesis
	IFN-gamma pathway
	ErbB1 downstream signaling
	ATF-2 transcription factor network
	ErbB2/ErbB3 signaling events
	ALK1 signaling events
	PDGFR-beta signaling pathway
	Neurotrophic factor-mediated Trk receptor signaling
	Syndecan-1-mediated signaling events
	Retinoic acid receptors-mediated signaling
	Nongenotropic Androgen signaling
	CXCR3-mediated signaling events
	VEGFR1 specific signals
	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-2-mediated signaling events
Cellular roles of Anthrax toxin
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
VEGFR3 signaling in lymphatic endothelium
Alpha-synuclein signaling
FGF signaling pathway
Signaling events mediated by focal adhesion kinase
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
	Fc Epsilon Receptor I Signaling in Mast Cells
	Insulin Signalling
Reactome	MAPK3 (ERK1) activation
	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cyclin B2 mediated events
	Golgi Cisternae Pericentriolar Stack Reorganization
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	Phosphorylation of the APC/C
	Phosphorylation of Emi1
	Condensation of Prophase Chromosomes
	MASTL Facilitates Mitotic Progression
	Resolution of Sister Chromatid Cohesion
	Condensation of Prometaphase Chromosomes
	Regulation of PLK1 Activity at G2/M Transition
	Activation of NIMA Kinases NEK9, NEK6, NEK7
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Recruitment of NuMA to mitotic centrosomes
	Depolymerisation of the Nuclear Lamina
	Anchoring of the basal body to the plasma membrane
	MAPK6/MAPK4 signaling
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	G2/M DNA replication checkpoint
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-195253:Degradation of beta-catenin by the destruction complex
	AKT phosphorylates targets in the cytosol
	Regulation of HSF1-mediated heat shock response
	CRMPs in Sema3A signaling
	Disassembly of the destruction complex and recruitment of AXIN to the membrane
	S33 mutants of beta-catenin aren't phosphorylated
	S37 mutants of beta-catenin aren't phosphorylated
	S45 mutants of beta-catenin aren't phosphorylated
	T41 mutants of beta-catenin aren't phosphorylated
	Degradation of GLI2 by the proteasome
	Constitutive Signaling by AKT1 E17K in CancerR-HSA-198323:AKT phosphorylates targets in the cytosol
	XBP1(S) activates chaperone genes
	Constitutive Signaling by AKT1 E17K in CancerR-HSA-112409:RAF-independent MAPK1/3 activation
	MAPK1 (ERK2) activation
	ERK/MAPK targets
	Regulation of actin dynamics for phagocytic cup formation
	Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	Oncogene Induced Senescence
	FCERI mediated MAPK activation
	NCAM signaling for neurite out-growth
	Recycling pathway of L1
	CREB phosphorylation through the activation of Ras
	Activation of the AP-1 family of transcription factors
	Thrombin signalling through proteinase activated receptors (PARs)
	Negative regulation of FGFR1 signaling
	Negative regulation of FGFR2 signaling
	Negative regulation of FGFR3 signaling
	Negative regulation of FGFR4 signaling
	RHO GTPases Activate WASPs and WAVEs
	RAF/MAP kinase cascade
	MAP2K and MAPK activation
	Negative feedback regulation of MAPK pathway
	Negative regulation of MAPK pathway
	Signal attenuation
	Advanced glycosylation endproduct receptor signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Growth hormone receptor signaling
WikiPathways	DNA Damage Response
	G1 to S cell cycle control
	TGF beta Signaling Pathway
	PPAR Alpha Pathway
	MAP kinase activation in TLR cascade
	RAF/MAP kinase cascade
	Mitotic Prophase
	Mitotic Prometaphase
	BMI1
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Prostate Cancer
	Regulation of Microtubule Cytoskeleton
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP710:DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Notch Signaling Pathway
	Glycogen Metabolism
	Insulin Signaling
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	IL-6 signaling pathway
	Wnt Signaling Pathway Netpath
	Copper homeostasis
	Focal Adhesion
	Hair Follicle Development: Induction (Part 1 of 3)
	Cardiac Hypertrophic Response
	Degradation of beta-catenin by the destruction complex
	T-Cell Receptor and Co-stimulatory Signaling
	Cardiac Progenitor Differentiation
	BDNF signaling pathway
	Corticotropin-releasing hormone
	B Cell Receptor Signaling Pathway
	IL17 signaling pathway
	Neural Crest Differentiation
	Alzheimers Disease
	IL-7 Signaling Pathway
	TWEAK Signaling Pathway
	Leptin signaling pathway
	Semaphorin interactions
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
	IL-5 Signaling PathwayWP500:Glycogen Metabolism
	Activation of Chaperone Genes by XBP1(S)
	Integrated Pancreatic Cancer Pathway
	Integrated Breast Cancer Pathway
	SREBP signalling
	IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
	Serotonin Receptor 4/6/7 and NR3C Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Serotonin HTR1 Group and FOS Pathway
	Vitamin A and Carotenoid Metabolism
	DNA Damage Response (only ATM dependent)
	TCR Signaling Pathway
	ErbB Signaling Pathway
	Hypothetical Network for Drug Addiction
	EPO Receptor Signaling
	Regulation of Actin Cytoskeleton
IL-2 Signaling Pathway
EGF/EGFR Signaling Pathway
MAPK Cascade
IL-4 Signaling Pathway
MAPK Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Apoptosis-related network due to altered Notch3 in ovarian cancer
IL-3 Signaling Pathway
Bladder Cancer
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
EBV LMP1 signaling
Signal Transduction of S1P Receptor
Nifedipine Activity
Aryl Hydrocarbon Receptor
PDGF Pathway
Alpha 6 Beta 4 signaling pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TNF alpha Signaling Pathway
Signaling Pathways in Glioblastoma
TSLP Signaling Pathway
IL-9 Signaling Pathway
Endothelin Pathways
FSH signaling pathway
RANKL/RANK Signaling Pathway
Opioid Signalling
IL-1 signaling pathway
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
Integrin-mediated Cell Adhesion
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Type II diabetes mellitus
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling Pathway
References
Ref 525550	Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes. 1999 Aug;48(8):1662-6.
Ref 526553	Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

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Prof. Feng ZHU

Prof. Yuzong CHEN