Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0YO6E
|
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| Former ID |
DIB009708
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| Drug Name |
PD-132301-2
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| Drug Type |
Small molecular drug
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Terminated | [1] | ||
| Company |
Parke-Davis & Co
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H40ClN3O
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| Canonical SMILES |
c1(NC(=O)NCC2(c3ccc(N(C)C)cc3)CCCC2)c(C(C)C)cccc1C(C)C.<br />Cl
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| CAS Number |
CAS 133825-81-7
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002679) | ||||
| REF 2 | Divergent pharmacologic activities of PD 132301-2 and CL 277,082, urea inhibitors of acyl-CoA:cholesterol acyltransferase. J Pharmacol Exp Ther. 1993 Nov;267(2):734-43. | ||||
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