Drug General Information
Drug ID	D0YO6E
Former ID	DIB009708
Drug Name	PD-132301-2
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[545279]
Company	Parke-Davis & Co
Structure		Download 2D MOL 3D MOL
Formula	C27H40ClN3O
Canonical SMILES	c1(NC(=O)NCC2(c3ccc(N(C)C)cc3)CCCC2)c(C(C)C)cccc1C(C)C.<br />Cl
CAS Number	CAS 133825-81-7
PubChem Compound ID	131678
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[533950]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545279	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002679)
Ref 533950	Divergent pharmacologic activities of PD 132301-2 and CL 277,082, urea inhibitors of acyl-CoA:cholesterol acyltransferase. J Pharmacol Exp Ther. 1993 Nov;267(2):734-43.

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