Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Z0EH
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| Former ID |
DIB009038
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| Drug Name |
PheTQS
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| Synonyms |
PheTQS; Alpha7 nicotinic acetylcholine receptor positive allosteric modulators (PAMs) (CNS disorders), GlaxoSmithKline; Alpha7 nicotinic acetylcholine receptor positive allosteric modulators (PAMs) (CNS disorders), Proximagen
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| Indication | Central nervous system disease [ICD10:G00-G99] | Investigative | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
c1(ccc2c(c1)[C@@H]1[C@H]([C@H](N2)c2ccc(cc2)C)CC=C1)S(=<br />O)(=O)N
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| Target and Pathway | |||||
| Target(s) | Neuronal acetylcholine receptor protein, alpha-7 chain | Target Info | Modulator | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Cholinergic synapse | |||||
| Nicotine addiction | |||||
| Chemical carcinogenesis | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). | ||||
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