Drug General Information
Drug ID	D0Z1PA
Former ID	DIB009945
Drug Name	GG-818
Synonyms	GI-231818; GW-1818
Indication	Prostate disease [ICD10:N42.9]		Investigative	[534666]
Company	Glaxo Wellcome plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S(=O)(=O)(c1c(ccc(c1)CCN1CCC(c2nc(c(o2)c2ccc(cc2)F)COCC<br />(F)(F)F)CC1)OC)N
CAS Number	CAS 179535-60-5
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Antagonist	[534666]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK Signaling
References
Ref 534666	In situ salt screening--a useful technique for discovery support and preformulation studies. Pharm Dev Technol. 1998 May;3(2):215-23.
Ref 534666	In situ salt screening--a useful technique for discovery support and preformulation studies. Pharm Dev Technol. 1998 May;3(2):215-23.

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