Drug Information

Drug General Information
Drug ID
D0Z2UD
Former ID
DIB012560
Drug Name
RS-100975
Synonyms
RS-97078; Ro-70-0004
Drug Type
Small molecular drug
Indication Prostate disease [ICD10:N42.9] Discontinued in Phase 1 [468114], [547119]
Company
Roche Bioscience
Structure
Download
2D MOL

3D MOL
Formula
C20H24F4N4O3
InChI
InChI=1S/C20H24F4N4O3/c1-14-12-25-19(30)28(18(14)29)6-2-5-26-7-9-27(10-8-26)16-4-3-15(21)11-17(16)31-13-20(22,23)24/h3-4,11-12H,2,5-10,13H2,1H3,(H,25,30)
InChIKey
WEZFJPKJUIGDPS-UHFFFAOYSA-N
CAS Number
CAS 186386-21-0
PubChem Compound ID
9872515
PubChem Substance ID
14930695, 24162785, 45294772, 80296876, 85209267, 103194365, 104046712, 134342140, 135650925, 233392187
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [525514]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 468114(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 497).
Ref 547119Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013213)
Ref 525514In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8.

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