Drug General Information
Drug ID	D0Z6VR
Former ID	DNC000357
Drug Name	Buthionine sulfoximine
Drug Type	Small molecular drug
Indication	Cancer; Malaria [ICD9: 140-229; ICD10:C00-C96, B54]		Investigative	[536365]
Structure		Download 2D MOL 3D MOL
Formula	C8H18N2O3S
Canonical SMILES	CCCCS(=N)(=O)CCC(C(=O)[O-])[NH3+]
InChI	1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
InChIKey	KJQFBVYMGADDTQ-UHFFFAOYSA-N
CAS Number	CAS 83730-53-4
PubChem Compound ID	3529580
PubChem Substance ID	4762418, 9737877, 80541521, 112296396
Target and Pathway
Target(s)	Glutamate--cysteine ligase regulatorysubunit	Target Info	Inhibitor	[536365]
KEGG Pathway	Glutathione metabolism
	Metabolic pathways
PathWhiz Pathway	Glutamate Metabolism
	Glutathione Metabolism
	Cysteine Metabolism
WikiPathways	Transcriptional activation by NRF2
	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Metabolism of amino acids and derivatives
	Trans-sulfuration and one carbon metabolism
	Trans-sulfuration pathway
	Phase II conjugation
	Glutathione metabolism
References
Ref 536365	Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 536365	Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.

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