Drug Information

Drug General Information
Drug ID
D0Z7FU
Former ID
DIB014033
Drug Name
INS 316
Drug Type
Small molecular drug
Indication Lung cancer [ICD9: 162; ICD10:C33-C34] Discontinued in Phase 3 [546461]
Company
Inspire Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C9H15N2O15P3
Canonical SMILES
C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O<br />)O)O)O
InChI
1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey
PGAVKCOVUIYSFO-XVFCMESISA-N
PubChem Compound ID
6133
PubChem Substance ID
3375, 584151, 831552, 833275, 833716, 841750, 855457, 7838933, 7891028, 7980869, 8027183, 8027189, 8143371, 8153844, 11335444, 11360683, 11364591, 11367153, 11369715, 11372791, 11374619, 11377877, 11461655, 11484245, 11488341, 11491411, 11492666, 11495511, 14720137, 14761469, 14932630, 17436071, 17436075, 24277146, 24277190, 24775910, 26706259, 26736753, 26737220, 26756678, 29225136, 47365080, 47662170, 47810645, 50061760, 53788170, 56312062, 56312125, 56312759, 56312760
Target and Pathway
Target(s) P2Y purinoceptor 2 Target Info Modulator [526114]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL5 Signaling Pathway
Reactome G alpha (q) signalling events
P2Y receptors
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 546461Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008257)
Ref 526114Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study. Pediatr Pulmonol. 2001 Aug;32(2):122-8.

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