Drug Information

Drug General Information
Drug ID
D0Z8YZ
Former ID
DIB018738
Drug Name
AC265347
Synonyms
AC-265347; AC 265347
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540568]
Structure
Download
2D MOL
Formula
C17H17NOS
InChI
InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3
InChIKey
IGSZVEPQZANNAB-UHFFFAOYSA-N
PubChem Compound ID
52943938
PubChem Substance ID
123089741, 162247417, 174006277, 178100774, 223704955
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Modulator (allosteric modulator) [531336]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 540568(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3947).
Ref 531336Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J Pharmacol Exp Ther. 2011 Apr;337(1):275-84.

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