TTD | Drug: D0ZJ6Y

Drug General Information
Drug ID	D0ZJ6Y
Former ID	DIB021247
Drug Name	YM44778
Synonyms	YM-44778
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539344]
Structure		Download 2D MOL
Formula	C34H39Cl2N3O5
InChI	InChI=1S/C34H39Cl2N3O5/c1-38(33(41)25-18-29(42-2)32(44-4)30(19-25)43-3)21-24(22-9-10-27(35)28(36)17-22)11-14-39-15-12-34(13-16-39)26-8-6-5-7-23(26)20-31(40)37-34/h5-10,17-19,24H,11-16,20-21H2,1-4H3,(H,37,40)
InChIKey	RMRHFQVHSFCBEO-UHFFFAOYSA-N
PubChem Compound ID	9852373
PubChem Substance ID	14814474, 24147790, 45274694, 79930915, 85220920, 135651346, 229135127
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Antagonist	[526310]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539344	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2120).
Ref 526310	Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102.

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Drug Information