Drug Information

Drug General Information
Drug ID
D0ZM5O
Former ID
DCL000923
Drug Name
Pexacerfont
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Phase 2/3 [522037]
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C18H24N6O
Canonical SMILES
CCC(C)NC1=NC(=NC2=C(C(=NN21)C)C3=C(N=C(C=C3)OC)C)C
InChI
1S/C18H24N6O/c1-7-10(2)19-18-22-13(5)21-17-16(12(4)23-24(17)18)14-8-9-15(25-6)20-11(14)3/h8-10H,7H2,1-6H3,(H,19,21,22)/t10-/m1/s1
InChIKey
LBWQSAZEYIZZCE-SNVBAGLBSA-N
CAS Number
CAS 459856-18-9
PubChem Compound ID
9884366
PubChem Substance ID
14851483, 14895797, 24171319, 45631308, 75151876, 81054919, 103652427, 104178907, 135252143, 135626743, 137248703, 139483614, 163679240, 198985503, 231088048, 245401894
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [536580]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 522037ClinicalTrials.gov (NCT00481325) Study of Pexacerfont (BMS-562086) in the Treatment of Outpatients With Generalized Anxiety Disorder. U.S. National Institutes of Health.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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