| Drug General Information |
| Drug ID |
D0ZS3F
|
| Former ID |
DNC011907
|
| Drug Name |
6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H14N2O5
|
| Canonical SMILES |
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=CC(=C3)[N+](=O)[O-]
|
| InChI |
1S/C17H14N2O5/c1-22-16-9-13-14(10-17(16)23-2)18-7-6-15(13)24-12-5-3-4-11(8-12)19(20)21/h3-10H,1-2H3
|
| InChIKey |
OMYGYNKHKZLDSH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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MAPK signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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PI3K-Akt signaling pathway
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Focal adhesion
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Gap junction
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Regulation of actin cytoskeleton
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HTLV-I infection
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Pathways in cancer
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MicroRNAs in cancer
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Glioma
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Prostate cancer
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Melanoma
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Central carbon metabolism in cancer
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Choline metabolism in cancer
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PANTHER Pathway
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Angiogenesis
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PDGF signaling pathway
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Pathway Interaction Database
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Signaling events mediated by PTP1B
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Beta3 integrin cell surface interactions
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S1P3 pathway
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Nectin adhesion pathway
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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PDGFR-beta signaling pathway
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Validated targets of C-MYC transcriptional repression
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PDGF receptor signaling network
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Reactome
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PIP3 activates AKT signaling
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Constitutive Signaling by Aberrant PI3K in Cancer
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RAF/MAP kinase cascade
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WikiPathways
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Regulation of Actin Cytoskeleton
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MAPK Signaling Pathway
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Osteoblast Signaling
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Focal Adhesion
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PIP3 activates AKT signaling
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PDGF Pathway
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Signaling Pathways in Glioblastoma
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Signaling by PDGF
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| References |
| REF 1 | A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). |
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