Drug Information

Drug General Information
Drug ID
D0ZT4J
Former ID
DCL000012
Drug Name
JSM 6427
Indication Macular degeneration [ICD9: 362.5; ICD10:H35.3] Phase 1 [522128]
Company
Jerini AG
Target and Pathway
Target(s) Integrin alpha-5 Target Info Antagonist [536198], [536506], [536855]
Integrin beta-1 Target Info Antagonist [536198], [536506], [536855]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Shigellosis
Pertussis
Proteoglycans in cancer
MicroRNAs in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04015:Rap1 signaling pathway
Axon guidance
Cell adhesion molecules (CAMs)
Platelet activation
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Leishmaniasis
Toxoplasmosis
Pathways in cancer
Small cell lung cancer
Dilated cardiomyopathy
NetPath Pathway IL6 Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Integrin signalling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Integrin signalling pathway
CCKR signaling map ST
Pathway Interaction Database Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Arf6 trafficking events
Angiopoietin receptor Tie2-mediated signaling
CXCR4-mediated signaling events
Plexin-D1 Signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Syndecan-2-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
RhoA signaling pathway
Reelin signaling pathway
Signaling events mediated by TCPTP
Alpha9 beta1 integrin signaling events
a4b7 Integrin signaling
a6b1 and a6b4 Integrin signaling
Validated targets of C-MYC transcriptional repression
Alpha4 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinase
Reactome Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactionsR-HSA-1566948:Elastic fibre formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Platelet Adhesion to exposed collagen
WikiPathways Focal Adhesion
Extracellular matrix organization
Elastic fibre formation
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wallWP366:TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Hair Follicle Development: Organogenesis (Part 2 of 3)
Nanoparticle-mediated activation of receptor signaling
JAK/STAT
Primary Focal Segmental Glomerulosclerosis FSGS
Pathogenic Escherichia coli infection
Neural Crest Differentiation
Semaphorin interactions
Platelet Adhesion to exposed collagen
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Cell junction organization
References
Ref 522128ClinicalTrials.gov (NCT00536016) A Phase 1 Safety Study of Single and Repeated Doses of JSM6427 (Intravitreal Injection) to Treat AMD. U.S. National Institutes of Health.
Ref 536198Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist. Mol Pharmacol. 2006 Jun;69(6):1820-8. Epub 2006 Mar 9.
Ref 536506Modulation of hypoxia-induced neovascularization by JSM6427, an integrin alpha5beta1 inhibiting molecule. Curr Eye Res. 2007 Sep;32(9):801-12.
Ref 536855An alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell Neurosci. 2008 Dec;39(4):579-85. Epub 2008 Sep 4.

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