Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZU9R
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| Former ID |
DAP000169
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| Drug Name |
Ritonavir
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| Synonyms |
Norvir; RIT; RTV; Norvir Sec; Ritonavir [USAN]; ABT 538; ABT 84538; ABT538; Abbott 84538; A-84538; ABBOTT-84538; ABT-538; DRG-0244; Norvir (TM); Norvir (TN); Ritonavir (JAN/USAN/INN); N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide; 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate; 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S)-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate; 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate; 538, ABT
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] | Approved | [536361] | ||
| Therapeutic Class |
Anti-HIV Agents
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| Company |
Abbott Laboratories
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| Structure |
|
Download2D MOL |
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| Formula |
C37H48N6O5S2
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| Canonical SMILES |
CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2<br />)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
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| InChI |
1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
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| InChIKey |
NCDNCNXCDXHOMX-XGKFQTDJSA-N
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| CAS Number |
CAS 155213-67-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9449, 523930, 583815, 612199, 822215, 827183, 855141, 7847493, 7890279, 7980525, 8030461, 10279496, 11528746, 12014859, 14766505, 14790837, 17422094, 26719904, 29215414, 46386817, 46392172, 46393138, 46505050, 49681649, 53789763, 57402349, 71825024, 79712259, 81092847, 92308258, 92711419, 93166545, 93167041, 99436927, 103244854, 104178993, 104616751, 104829353, 117877983, 118048821, 124658994, 124757062, 124801360, 124876828, 124892213, 124894323, 125163866, 125333191, 126592976, 126630875
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| SuperDrug ATC ID |
J05AE03
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| SuperDrug CAS ID |
cas=155213675
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | HIV protease | Target Info | Inhibitor | [535213], [536999] | |
| References | |||||
| Ref 535213 | Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. J Biol Chem. 2001 Sep 7;276(36):33309-12. Epub 2001 Jul 20. | ||||
| Ref 536999 | Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20. Epub 2008 Dec 23. | ||||
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