Drug Information

Drug General Information
Drug ID
D0ZU9Z
Former ID
DIB020277
Drug Name
LY320135
Synonyms
LY 320135; LY-320135
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542444]
Structure
Download
2D MOL
Formula
C24H17NO4
InChI
InChI=1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3
InChIKey
RYNSGDFWBJWWSZ-UHFFFAOYSA-N
PubChem Compound ID
5311257
PubChem Substance ID
7979825, 11056385, 14878087, 26753297, 39340961, 57309758, 57359407, 75783703, 85209155, 85788701, 103567317, 114155682, 124891595, 129200182, 135309795, 135337496, 135650548, 135698232, 136353063, 137066043, 141566793, 162023390, 162247377, 163123871, 172841720, 176227145, 184538767, 198974090, 202558953, 204369924, 215781298, 223468606, 223532833, 225373242, 229726154, 251960633, 252141330, 252156472, 252266394, 252373266, 252451046
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [534541]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 542444(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 742).
Ref 534541LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan;284(1):291-7.

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