Drug Information

Drug General Information
Drug ID
DX1CLZ
Drug Name
N-[3-(5-methoxythien-2-yl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-2,2-dimethylhydrazinecarboxamide
Synonyms
CHEMBL325453
Indication Discovery agent Investigative [1587926]
Formula
C18H17N5O3S
Canonical SMILES
COc1ccc(s1)c2[nH]nc3c4cccc(NC(=O)NN(C)C)c4C(=O)c23
InChI
InChI=1S/C18H17N5O3S/c1-23(2)22-18(25)19-10-6-4-5-9-13(10)17(24)14-15(9)20-21-16(14)11-7-8-12(26-3)27-11/h4-8H,1-3H3,(H,20,21)(H2,19,22,25)
InChIKey
VWMKXSIQIRRBPL-UHFFFAOYSA-N
Target and Pathway
Target(s) Cell division protein kinase 4 Target Info [1587926]
G1/S-specific cyclin E1 Target Info [1587926]
KEGG Pathway Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Tight junction
T cell receptor signaling pathway
Hepatitis B
Measles
HTLV-I infection
Pathways in cancer
Viral carcinogenesis
Pancreatic cancer
Glioma
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancerhsa04110:Cell cycle
Oocyte meiosis
MicroRNAs in cancer
Prostate cancer
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Cell cycle
Parkinson disease
p53 pathway
p53 pathway feedback loops 2
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Validated targets of C-MYC transcriptional activation
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of retinoblastoma proteinprlsignalingeventspathway:Signaling events mediated by PRL
E2F transcription factor network
mTOR signaling pathway
BARD1 signaling events
PLK3 signaling events
Regulation of retinoblastoma protein
Reactome Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
Meiotic recombinationR-HSA-113510:E2F mediated regulation of DNA replication
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
p53-Dependent G1 DNA Damage Response
WikiPathways DNA Damage Response
G1 to S cell cycle control
Ovarian Infertility Genes
PPAR Alpha Pathway
Bladder Cancer
S Phase
Transcriptional Regulation of White Adipocyte Differentiation
Meiotic Recombination
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G1-G1/S phases
Cell Cycle
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
ID signaling pathway
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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