Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX1S0P
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| Drug Name |
6-[4-(4-Acetyl-piperazin-1-yl)-phenoxymethyl]-7-[2-(4,4-difluoro-cyclohexyl)-ethyl]-7Hpyrrolo[2,3-d]pyrimidine-2-carbonitrile
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| Synonyms |
CHEMBL461619
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C28H32F2N6O2
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| Canonical SMILES |
CC(=O)N1CCN(CC1)c2ccc(OCc3cc4cnc(nc4n3CCC5CCC(F)(F)CC5)C#N)cc2
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| InChI |
InChI=1S/C28H32F2N6O2/c1-20(37)34-12-14-35(15-13-34)23-2-4-25(5-3-23)38-19-24-16-22-18-32-26(17-31)33-27(22)36(24)11-8-21-6-9-28(29,30)10-7-21/h2-5,16,18,21H,6-15,19H2,1H3
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| InChIKey |
DYLHJNWFUXMPCG-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin L | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| References | |||||
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