Drug Information
| Drug General Information | |||||
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| Drug ID |
DX4Q2V
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| Drug Name |
(3R,5S)-5-((4-(1-(thiophen-3-ylsulfonyl)-1H-indol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL452768
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H26N6O5S3
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| Canonical SMILES |
O=C(O[C@H]1CN[C@@H](C1)C#Cc2cc3ncnc(Nc4ccc5c(ccn5S(=O)(=O)c6ccsc6)c4)c3s2)N7CCOCC7
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| InChI |
InChI=1S/C29H26N6O5S3/c36-29(34-8-10-39-11-9-34)40-22-14-20(30-16-22)1-3-23-15-25-27(42-23)28(32-18-31-25)33-21-2-4-26-19(13-21)5-7-35(26)43(37,38)24-6-12-41-17-24/h2,4-7,12-13,15,17-18,20,22,30H,8-11,14,16H2,(H,31,32,33)/t20-,22-/m1/s1
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| InChIKey |
HAYQBGMCBFKTMA-IFMALSPDSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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