Drug Information
Drug General Information | |||||
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Drug ID |
DX7C7I
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Drug Name |
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)thiophen-2-yl)thieno[2,3-d]pyrimidin-4-amine
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Synonyms |
CHEMBL481324
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Indication | Discovery agent | Investigative | [1587926] | ||
Formula |
C27H24ClFN4O3S3
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Canonical SMILES |
CS(=O)(=O)CCNCc1ccc(s1)c2cc3c(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)ncnc3s2
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InChI |
InChI=1S/C27H24ClFN4O3S3/c1-39(34,35)10-9-30-14-20-6-8-24(37-20)25-13-21-26(31-16-32-27(21)38-25)33-19-5-7-23(22(28)12-19)36-15-17-3-2-4-18(29)11-17/h2-8,11-13,16,30H,9-10,14-15H2,1H3,(H,31,32,33)
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InChIKey |
VKGQZQGDXLIZTP-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
KEGG Pathway | ErbB signaling pathway | ||||
Calcium signaling pathway | |||||
HIF-1 signaling pathway | |||||
Focal adhesion | |||||
Adherens junction | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Prostate cancer | |||||
Bladder cancer | |||||
Non-small cell lung cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
EGF receptor signaling pathway | |||||
PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
ErbB Signaling Pathway | |||||
EGF/EGFR Signaling Pathway | |||||
Focal Adhesion | |||||
Extracellular vesicle-mediated signaling in recipient cells | |||||
Bladder Cancer | |||||
Signaling by ERBB2 | |||||
Integrated Pancreatic Cancer Pathway | |||||
Signaling Pathways in Glioblastoma | |||||
Leptin signaling pathway | |||||
miR-targeted genes in muscle cell - TarBase | |||||
Semaphorin interactions | |||||
References |
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