Drug Information

Drug General Information
Drug ID
DX7UPV
Drug Name
N-(4-fluorophenyl)-2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazole-5-carboxamide
Synonyms
CHEMBL202567
Indication Discovery agent Investigative [1587926]
Formula
C26H27FN6O4S
Canonical SMILES
COc1cc2c(Nc3ncc(s3)C(=O)Nc4ccc(F)cc4)ncnc2cc1OCCCN5CCOCC5
InChI
InChI=1S/C26H27FN6O4S/c1-35-21-13-19-20(14-22(21)37-10-2-7-33-8-11-36-12-9-33)29-16-30-24(19)32-26-28-15-23(38-26)25(34)31-18-5-3-17(27)4-6-18/h3-6,13-16H,2,7-12H2,1H3,(H,31,34)(H,28,29,30,32)
InChIKey
GUKNWLMFOBWSRH-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.