Drug Information

Drug General Information
Drug ID
DX9DG2
Drug Name
7-(5-(2-(piperidin-1-yl)ethoxy)-1H-indol-2-yl)isoindolin-1-one
Synonyms
CHEMBL484876
Indication Discovery agent Investigative [1587926]
Formula
C23H25N3O2
Canonical SMILES
O=C1NCc2cccc(c3cc4cc(OCCN5CCCCC5)ccc4[nH]3)c12
InChI
InChI=1S/C23H25N3O2/c27-23-22-16(15-24-23)5-4-6-19(22)21-14-17-13-18(7-8-20(17)25-21)28-12-11-26-9-2-1-3-10-26/h4-8,13-14,25H,1-3,9-12,15H2,(H,24,27)
InChIKey
PNTVOXMDTWOXGG-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Vascular endothelial growth factor receptor 2 Target Info [1587926]
Vascular endothelial growth factor receptor 2 Target Info [1587926]
Aurora kinase A Target Info [1587926]
KEGG Pathway Oocyte meiosishsa04014:Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalinghif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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