Drug Information

Drug General Information
Drug ID
DX9GP3
Drug Name
5-Ethyl-7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-6-oxo-1Himidazo[4,5-f]indole
Synonyms
CHEMBL469197
Indication Discovery agent Investigative [1587926]
Formula
C17H19N5O
Canonical SMILES
CCN1C(=O)C(C)(C)c2cc3[nH]c(nc3cc12)c4cc(C)[nH]n4
InChI
InChI=1S/C17H19N5O/c1-5-22-14-8-12-11(7-10(14)17(3,4)16(22)23)18-15(19-12)13-6-9(2)20-21-13/h6-8H,5H2,1-4H3,(H,18,19)(H,20,21)
InChIKey
QRFIOQPCVMNZPT-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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