Drug Information

Drug General Information
Drug ID
DXC1EL
Drug Name
2-[3-(2-Hydroxy-benzoylamino)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL344587
Indication Discovery agent Investigative [1587926]
Formula
C23H21N3O6S
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)c3cccc(NC(=O)c4ccccc4O)c3
InChI
InChI=1S/C23H21N3O6S/c27-21-11-4-3-10-19(21)22(28)24-17-8-5-9-18(13-17)33(31,32)26-14-16-7-2-1-6-15(16)12-20(26)23(29)25-30/h1-11,13,20,27,30H,12,14H2,(H,24,28)(H,25,29)
InChIKey
JROHDXNIWULULC-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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