Drug Information

Drug General Information
Drug ID
DXD1AT
Drug Name
8-Chloro-11-[1-(2-pyridin-4-yl-acetyl)-piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-3-carbonitrile
Synonyms
CHEMBL335730
Indication Discovery agent Investigative [1587926]
Formula
C27H23ClN4O
Canonical SMILES
Clc1ccc2C(=C3CCN(CC3)C(=O)Cc4ccncc4)c5ncc(cc5CCc2c1)C#N
InChI
InChI=1S/C27H23ClN4O/c28-23-3-4-24-21(15-23)1-2-22-13-19(16-29)17-31-27(22)26(24)20-7-11-32(12-8-20)25(33)14-18-5-9-30-10-6-18/h3-6,9-10,13,15,17H,1-2,7-8,11-12,14H2
InChIKey
AMUVTFDBOFEYBQ-UHFFFAOYSA-N
Target and Pathway
Target(s) Farnesyltransferase Target Info [1587926]
Protein farnesyltransferase beta subunit Target Info [1587926]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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