Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXL6HI
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| Drug Name |
(R)-2-{3'-[2-(4-tert-butyl-piperazin-1-yl)-thiazol-4-yl]-biphenyl-3-yl}-4-methyl-pentanoic acid cyanomethyl-amide
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| Synonyms |
CHEMBL212879
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C31H39N5OS
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| Canonical SMILES |
CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)c2cccc(c2)c3csc(n3)N4CCN(CC4)C(C)(C)C
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| InChI |
InChI=1S/C31H39N5OS/c1-22(2)18-27(29(37)33-13-12-32)25-10-6-8-23(19-25)24-9-7-11-26(20-24)28-21-38-30(34-28)35-14-16-36(17-15-35)31(3,4)5/h6-11,19-22,27H,13-18H2,1-5H3,(H,33,37)/t27-/m1/s1
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| InChIKey |
NSIRSTDMOKGKBU-HHHXNRCGSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin L | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| References | |||||
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