Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXP39E
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| Drug Name |
2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-5-carboxylic acid (1-methyl-4-phenyl-piperidin-4-ylmethyl)-amide
|
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| Synonyms |
CHEMBL508319
|
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C28H36N6O
|
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| Canonical SMILES |
CN1CCC(CNC(=O)c2cnc(nc2NCC3CCC4(CC3)CC4)C#N)(CC1)c5ccccc5
|
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| InChI |
InChI=1S/C28H36N6O/c1-34-15-13-28(14-16-34,22-5-3-2-4-6-22)20-32-26(35)23-19-30-24(17-29)33-25(23)31-18-21-7-9-27(10-8-21)11-12-27/h2-6,19,21H,7-16,18,20H2,1H3,(H,32,35)(H,30,31,33)
|
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| InChIKey |
FJKPOCSUBVDARQ-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin L | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| References | |||||
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