Drug Information

Drug General Information
Drug ID
DXT5EC
Drug Name
(Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-5-yl]benzenesulfonamide
Synonyms
CHEMBL1215284
Indication Discovery agent Investigative [1587926]
Formula
C30H32N4O4S
Canonical SMILES
O=C1CCCc2[nH]c(\\C=C\\3/C(=O)Nc4ccc(NS(=O)(=O)c5ccccc5)cc34)c(CCCN6CCCC6)c12
InChI
InChI=1S/C30H32N4O4S/c35-28-12-6-11-26-29(28)22(10-7-17-34-15-4-5-16-34)27(31-26)19-24-23-18-20(13-14-25(23)32-30(24)36)33-39(37,38)21-8-2-1-3-9-21/h1-3,8-9,13-14,18-19,31,33H,4-7,10-12,15-17H2,(H,32,36)/b24-19-
InChIKey
GFDMYTNCMHUIAT-CLCOLTQESA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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