Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (2-Bromo-phenyl)-[1-(3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-methanone | Drug Info |
| Ftase --- FPTase | [(R)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid benzyl ester | Drug Info |
| Ftase --- FPTase | 5-((2-cyanobenzyloxy)(1-methyl-1H-imidazol-5-yl)methyl)-2'-methylbiphenyl-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-oxo-acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-7-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-acetyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-3-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | SID103905591 | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-3-Methyl-2-{2-[1-(4-nitro-benzyl)-1H-imidazol-4-yl]-acetylamino}-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | Lithium; (S)-4-methylsulfanyl-2-({2'-methyl-5-[5-(4-trifluoromethyl-phenyl)-furan-2-ylmethoxymethyl]-biphenyl-2-carbonyl}-amino)-butyrate | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-phenyl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(2-nitro-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one | Drug Info |
| Ftase --- FPTase | 3-benzo[1,3]dioxol-5-yl-4-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-4-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methyl)quinoline-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid methyl-pyridin-3-yl-amide | Drug Info |
| Ftase --- FPTase | (S)-2-{[6-((R)-2-Amino-3-mercapto-propionylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 5-((E)-4,8-Dimethyl-nona-3,7-dienyl)-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-pyridin-2-ylethynyl-benzonitrile | Drug Info |
| Ftase --- FPTase | N-(adamantan-2-yl)-10-cyano-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.1^{3,7}.1^{9,13}.0^{15,19}]heptacosa-3(27),4,6,9(26),10,12,16,18-octaene-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-[3-(1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(2-cyclohexylethyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-({3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-2-[((R)-3-(4-hydroxy-phenyl)-2-{(E)-3-[((Z)-2-pent-1-enyl)-phenyl]-acryloylamino}-propionyl)-methyl-amino]-propionyl}-methyl-amino)-3-phenyl-propionic acid (S)-3,6-dioxo-piperazin-2-ylmethyl ester | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-dimethylamino-butyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy-biphenyl-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| Ftase --- FPTase | 4-{2-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-butyl-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(Hydroxy-diphenyl-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-(4-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-4-propoxy-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | Acetic acid (6aR,6bS,9S,10aR,12aS)-5-hydroxy-1,3-dimethoxy-6b,10,10,12a-tetramethyl-3,6,6a,6b,7,8,9,10,10a,11,12,12a-dodecahydro-1H-2,13-dioxa-benzo[a]cyclopenta[h]anthracen-9-yl ester | Drug Info |
| Ftase --- FPTase | 2-(3-Bromo-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | [[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-3-sulfonyl)-amino]-acetic acid tert-butyl ester | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3,5-Difluoro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-6-fluoro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 1-(3-Chloro-phenyl)-4-[3-(2-methoxy-4'-trifluoromethyl-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-3-yl-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 6-[(2'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Methoxy-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(Hydroxy-phenyl-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[6-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-trifluoromethyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
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