Drug General Information
Drug ID D01WJL
Drug Name Aminosalicylic Acid Drug Info
Synonyms Paser; Parasal; Aminosalicylic Acid Resin Complex; Rezipas
Drug Type Small molecular drug
Company Panray Corp Sub Ormont Drug And Chemical Co Inc
Structure D01WJL
Drug Resistance Mutations
Target Name Bacterial Thymidylate synthase (thyA) Target Info
Gene Name thyA
Uniprot ID TYSY_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELL
WFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLR
TDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIAS
YALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFE
YTYEDIVVKNYDPHPAIKAPVAV [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: R222G [555541]
Mutation info Missense: T202A [555541]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 555541The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul;53(1):275-82.

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