Drug General Information
Drug ID D03JRA
Drug Name Beta-lactam inhibitor Drug Info
Structure D03JRA
Drug Resistance Mutations
Target Name Bacterial Penicillin-binding protein 2B (PBP2)
Gene Name PBP2
Uniprot ID PBP2_NEIMB
Species Neisseria meningitidis
Reference Sequence MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAIAVLFAGLIARGLYLQTVTYNFLKEQ
GDNRIVRTQTLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLERLSELVDV
PVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIG
FTDIDGKGQEGLELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLD
QRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNR
AVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQ
KSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSF
GYGLQLSLLQLARAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEP
GGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHIATFIGFAPAKNPRVIVAVTIDEPTA
HGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS [Neisseria meningi
tidis]
Targeted Disease Neisseria Meningititis
Drug Resistance Mutations
Mutation info Missense: A501P [556229]
Mutation info Missense: A510V [556229]
Mutation info Missense: F504L [556229]
Mutation info Missense: G482S [556229]
Mutation info Missense: G545S [556229]
Mutation info Missense: I312M [556229]
Mutation info Missense: N512Y [556229]
Mutation info Missense: V316T [556229]
References
Ref 1572605The ChEMBL database in 2017.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.

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