Resistance mutation info of drug

Drug General Information
Drug ID D05HPI
Drug Name Daptomycin Drug Info
Synonyms Cidecin; Cubicin; Dapcin; Daptomicina; Daptomycine; Daptomycinum; Deptomycin; Daptomicina [Spanish]; Daptomycine [French]; Daptomycinum [Latin]; LY146032; Cubicin (TN); LY-146032; MK-3009; Daptomycin [USAN:INN:BAN]; Daptomycin (JAN/USAN/INN); N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone; N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
Drug Type Small molecular drug
Therapeutic Class Antibiotics
Company Cubist Pharmaceuticals
Structure D05HPI
Drug Resistance Mutations
Target Name Bacterial Cardiolipin synthase (cls)
Gene Name cls
Uniprot ID CLS_STAAN
Species Staphylococcus aureus
Reference Sequence MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGF
ILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLL
YNNAAFLTTDNDLKIYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKK
AEQGVEVKILYDDMGSRGLRKKGLRPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVI
DGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISY
DDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLD
SIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDD
EIASVGTANMDHRSFTLNFEVNAFIYDQQIAKKLKQAFIDDLAVSSELTKARYAKRSLWI
KFKEGISQLLSPIL [Staphylococcus aureus]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: A23V [556229]
Mutation info Missense: F60S [556229]
Mutation info Missense: L52F [556229]
Mutation info Missense: T33N [556229]
Mutation info Missense: H215R [1559233]
Mutation info Missense: R218Q [1559233]
Target Name Bacterial CDP-diacylglycerol--glycerol-3-phosphate (pgsA)
Gene Name pgsA
Uniprot ID PGSA_STAAN
Species Staphylococcus aureus
Reference Sequence MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFILASLSDFVD
GYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNSVVAIIIIAREFAVTGLRLL
QIEQGFVSAAGQLGKIKTAVTMVAITWLLLGDPLATLIGLSLGQILLYIGVIFTILSGIE
YFYKGRDVFKQK [Staphylococcus aureus]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: A64V [556229]
Mutation info Missense: K66R [556229]
Mutation info Missense: S177F [556229]
Mutation info Missense: V59N [556229]
Target Name Bacterial DNA-directed RNA polymerase subunit beta (rpoB) Target Info
Gene Name rpoB
Uniprot ID RPOB_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MLEGCILADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDS
FEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVD
ECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLV
RSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKA
LGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLF
FKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGG
VEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINI
RPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHY
GRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHV
VAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHD
DANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITV
MHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLL
VAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEV
LADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVP
HGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILP
VEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLP
DELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFP
YPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYG
AAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSS
DGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA [Mycobacterium tuberc
ulosis]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: A1085V [556229]
Mutation info Missense: A621E [556229]
Mutation info Missense: F632S [556229]
Mutation info Missense: I953S [556229]
Mutation info Missense: Q961K [556229]
Target Name Bacterial Phosphatidylglycerol (mprF)
Gene Name mprF
Uniprot ID MPRF_STAAN
Species Staphylococcus aureus
Reference Sequence MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGG
GASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYT
HDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFI
IYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALS
GLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGT
SAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDA
LYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYI
LITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYT
IEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSH
LIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVI
FYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEII
EPPFSTEFINELQHVSDLWLDNRQEMHFSVGQFNEEYLSKAPIGVMRNEENEVIAFCSLM
PTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSY
LRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK
[Staphylococcus aureus]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: F57S [556229]
Mutation info Missense: G61V [556229]
Mutation info Missense: I420N [556229]
Mutation info Missense: L341S [556229]
Mutation info Missense: L826F [556229]
Mutation info Missense: M347R [556229]
Mutation info Missense: P314L [556229]
Mutation info Missense: S295L [556229]
Mutation info Missense: S337L [556229]
Mutation info Missense: T345A [556229]
Mutation info Missense: T345I [556229]
Mutation info Missense: T345K [556229]
Mutation info Missense: T472K [556229]
Mutation info Missense: V351E [556229]
Target Name Bacterial Sensor histidine kinase (liaS)
Gene Name liaS
Uniprot ID A0A1B1EYN7_ENTFC
Species Enterococcus faecium
Reference Sequence MMGKISRAMLAVYSGIAAFLIILFSLFTYFYASNQSHWWGELLRARLLYVPLIFHLLAIS
LGVGLIVFLLLSLIQKTKYGKIEEKLRALSSDNYESKLLLLPIPSASDDLYIKDIDKEIT
KIKEKMIEVSSELQIVTSRPQYVDGQTKEEILELERHRLARELHDSVSQQLFAAMMMMSA
LTEQAEKSETPEMFRKQLKMVAEIINASQSEMRALLLHLRPVNLEEKSLKQGIEQLLKEL
QNKIQISLKWDVEDVKLSSSIEDHLFRIVQELLSNTLRHAKANELEVYLHKIDNNLLLRI
IDDGTGFNMNETKTGSYGLNNIKERVAGIGGTVKIISFKGQGTSVEIKVPLMKEA [Ent
erococcus faecium]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: A180T [556243]
Mutation info Missense: E192G [556243]
Mutation info Missense: H264Q [556243]
Mutation info Missense: T120A [556243]
References
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 1559233Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci.Antimicrob Agents Chemother.2013 Jan;57(1):289-96.

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