Resistance mutation info of drug

Drug General Information
Drug ID D05MQN
Drug Name Fluoroquinolones Drug Info
Drug Resistance Mutations
Target Name Bacterial DNA gyrase subunit A (gyrA)
Gene Name gyrA
Uniprot ID GYRA_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMF
DSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPG
NDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGG
IAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGT
ADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGIS
NIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQ
LIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAG
LIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVR
DELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRG
GKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLL
AFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELV
GAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREG
TYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSG
GGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN [
Mycobacterium tuberculosis]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: A74S [555615], [556243]
Mutation Prevalence 10 out of 49 isolates
Mutation info Missense: D94V [555632], [556243]
Mutation Prevalence 32 out of 71 isolates
Mutation info Missense: D87Y [556229], [556243]
Mutation info Missense: D87Y [556229], [556243]
Mutation info Missense: A90G [555580], [556243]
Mutation info Missense: T80A [555580], [556243]
Mutation info Missense: P102H [555592], [556243]
Mutation info Missense: D89N [555613], [556243]
Mutation info Missense: G88A [555613], [556243]
Mutation info Missense: L109V [555632], [556243]
Mutation info Missense: S95T [556170], [556243]
Mutation info Missense: A90V [556177], [556243]
Mutation info Missense: D94A [556177], [556243]
Mutation info Missense: D94G [556177], [556243]
Mutation info Missense: D94N [556177], [556243]
Mutation info Missense: D94Y [556177], [556243]
Mutation info Missense: S91P [556177], [556243]
Mutation info Missense: D87N [556229], [556243]
Mutation info Missense: D87N [556229], [556243]
Mutation info Missense: D87N [556229], [556243]
Mutation info Missense: D95N [556229], [556243]
Mutation info Missense: D95N [556229], [556243]
Mutation info Missense: S83F [556229]
Mutation info Missense: D94F [555731]
Mutation info Missense: D94H [556177]
Mutation info Missense: A384D [556229]
Mutation info Missense: D105G [556229]
Mutation info Missense: D95G [556229]
Mutation info Missense: E88A [556229]
Mutation info Missense: E88K [556229]
Mutation info Missense: H80P [556229]
Mutation info Missense: H80R [556229]
Mutation info Missense: N57K [556229]
Mutation info Missense: S101L [556229]
Mutation info Missense: S84L [556229]
Mutation info Missense: S85P [556229]
Mutation info Missense: S91F [556229]
Mutation info Missense: S97P [556229]
Mutation info Missense: T83I [556229]
Mutation info Missense: A91T [556243]
Mutation info Missense: D87G [556243]
Mutation info Missense: D87H [556243]
Mutation info Missense: D87V [556243]
Mutation info Missense: D89G [556243]
Mutation info Missense: D89V [556243]
Mutation info Missense: D90G [556243]
Mutation info Missense: D94T [556243]
Mutation info Missense: G80N [556243]
Mutation info Missense: G88C [556243]
Mutation info Missense: S83I [556243]
Mutation info Missense: S83L [556243]
Mutation info Missense: S83W [556243]
Mutation info Missense: S84Y [556243]
Mutation info Missense: T86I [556243]
Target Name Bacterial DNA gyrase subunit B (gyrB) Target Info
Gene Name gyrB
Uniprot ID GYRB_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV [Mycobacterium tuberculosis]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: D472H [555580], [555727]
Mutation info Missense: D472N [555584], [555727]
Mutation info Missense: D472A [555727]
Mutation info Missense: E512D [555727]
Mutation info Missense: E512V [555727]
Mutation info Missense: G481A [555727]
Mutation info Missense: S458F [555727]
Mutation info Missense: T511P [555727]
Mutation info Missense: D505A [555499]
Mutation info Missense: N510D [555580]
Mutation info Missense: A515T [555668]
Mutation Prevalence 1 out of 48 isolates
Mutation info Missense: A515V [555668]
Mutation Prevalence 3 out of 48 isolates
Mutation info Missense: Q510K [555668]
Mutation Prevalence 1 out of 48 isolates
Mutation info Missense: Q549H [555668]
Mutation Prevalence 1 out of 48 isolates
Mutation info Missense: R457C [555708]
Mutation info Missense: N510T [555727]
Mutation info Missense: A473V [556229]
Mutation info Missense: M437I [556229]
Mutation info Missense: V461G [556229]
Mutation info Missense: D476N [556243]
Target Name Bacterial DNA topoisomerase 4 subunit A (parC) Target Info
Gene Name parC
Uniprot ID PARC_ECOLI
Species Escherichia coli
Reference Sequence MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDI
PPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVR
MRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIV
PRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRR
RLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPL
QEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSN
QPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDA
GYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDL
PQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGE
RGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE [Escherichia coli]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: A85T [556229]
Mutation info Missense: D111H [556229]
Mutation info Missense: S129P [556229]
Mutation info Missense: S84F [556243]
Mutation info Missense: W106G [556229]
References
Ref 525081ClinicalTrials.gov (NCT02357407) Development of an Adjustment Assistance Tool Dosage of Fluoroquinolones in a Population Pharmacokinetic Model. U.S. National Institutes of Health.
Ref 555499Characterization of pyrazinamide and ofloxacin resistance among drug resistant Mycobacterium tuberculosis isolates from Singapore. Int J Infect Dis. 2002 Mar;6(1):48-51.
Ref 555580Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes. Antimicrob Agents Chemother. 2006 Jan;50(1):104-12.
Ref 555584Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand. Southeast Asian J Trop Med Public Health. 2005;36 Suppl 4:228-37.
Ref 555592Stepwise decrease in moxifloxacin susceptibility amongst clinical isolates of multidrug-resistant Mycobacterium tuberculosis: correlation with ofloxacin susceptibility. Microb Drug Resist. 2006 Spring;12(1):7-11.
Ref 555613High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens. Antimicrob Agents Chemother. 2006 Dec;50(12):4182-5. Epub 2006 Oct 2.
Ref 555615Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing. J Clin Microbiol. 2006 Dec;44(12):4566-8. Epub 2006 Oct 11.
Ref 555632Analysis of fluoroquinolone resistance in clinical isolates of Mycobacterium tuberculosis from India. J Chemother. 2007 Apr;19(2):166-71.
Ref 555668Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia. Antimicrob Agents Chemother. 2008 Aug;52(8):2937-9. doi: 10.1128/AAC.00036-08. Epub 2008 Jun 16.
Ref 555708Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2009 Aug;53(8):3248-55. doi: 10.1128/AAC.00079-09. Epub 2009 May 26.
Ref 555727Beijing genotype of Mycobacterium tuberculosis is significantly associated with high-level fluoroquinolone resistance in Vietnam. Antimicrob Agents Chemother. 2009 Nov;53(11):4835-9. doi: 10.1128/AAC.00541-09. Epub 2009 Aug 31.
Ref 555731Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones. J Clin Microbiol. 2009 Dec;47(12):3985-90. doi: 10.1128/JCM.01229-09. Epub 2009 Oct 21.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 556170Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing. Arch Pathol Lab Med. 1995 Feb;119(2):131-8.
Ref 556177Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrob Agents Chemother. 1994 Apr;38(4):773-80.

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