Resistance mutation info of drug

Drug General Information
Drug ID D07LVE
Drug Name Aminocoumarin Drug Info
Drug Resistance Mutations
Target Name Bacterial DNA gyrase subunit B (gyrB) Target Info
Gene Name gyrB
Uniprot ID GYRB_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV [Mycobacterium tuberculosis]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: R136G [556229], [556243]
Mutation info Missense: R136G [556229], [556243]
Mutation info Missense: G85S [556229]
Mutation info Missense: I102S [556229]
Mutation info Missense: I56S [556229]
Mutation info Missense: R144I [556229]
Mutation info Missense: R144S [556229]
Mutation info Missense: S128L [556229]
Mutation info Missense: T173A [556229]
Mutation info Missense: R136C [556243]
Mutation info Missense: R136E [556243]
Mutation info Missense: R136H [556243]
Mutation info Missense: R136I [556243]
Mutation info Missense: R136L [556243]
Mutation info Missense: R136S [556243]
Mutation info Missense: G78S [556229]
Mutation info Missense: G124S [556243]
Mutation info Missense: R184Q [556243]
Mutation info Missense: T214A [556243]
Mutation info Missense: T214I [556243]
References
Ref 1572605The ChEMBL database in 2017.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.

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