Resistance mutation info of drug

Drug General Information
Drug ID D07UHS
Drug Name Fingolimod Drug Info
Synonyms Gilenya (TN); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol
Drug Type Small molecular drug
Company Novartis
Structure D07UHS
Drug Resistance Mutations
Target Name Sphingosine 1-phosphate receptor 1 (S1PR1) Target Info
Gene Name S1PR1
Uniprot ID S1PR1_HUMAN
Species Homo sapiens
Reference Sequence MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS [Homo sapiens]
Targeted Disease Multiple sclerosis
Drug Resistance Mutations
Mutation info Missense: G305C [1559255]
Mutation info Missense: I45T [1559255]
References
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 539536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2407).
Ref 1559255Individual variation of human S1P?coding sequence leads to heterogeneity in receptor function and drug interactions.J Lipid Res.2014 Dec;55(12):2665-75.

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