Resistance mutation info of drug

Drug General Information
Drug ID D08QME
Drug Name Ethambutol Drug Info
Synonyms Aethambutolum; Diambutol; EMB; Etambutol; Etambutolo; Ethambutolum; Etibi; Miambutol; Myambutol; Purderal; Servambutol; Tibutol; Etambutolo [DCIT]; CL 40881 (dihydrochloride); D-Ethambutol; Etambutol [INN-Spanish]; Ethambutol & EEP; Ethambutol & Propolis; Ethambutol (INN); Ethambutol [INN:BAN]; Ethambutol, meso form; Ethambutol, racemic mixture; Ethambutolum [INN-Latin]; Myambutol (TN); Myambutol (dihydrochloride); Servambutol (TN); Ethambutol, (-)-isomer; D,N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-2,2'-(Ethylenediimino)bis(1-butanol); D-2,2'-(Ethylenediimino)di-1-butanol; (+)-(S,S)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (+)-2,2'-(Ethylenediimino)di-1-butanol; (+)-N,N'-Bis(1-(hydroxymethyl)propyl)ethylenediamine; (+)-S,S-Ethambutol; (+)-ethambutol; (-)-(R,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (2'S)-2,2'-[Ethane-1,2-diyldi(imino)]dibutan-1-ol; (2R)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2S)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol; (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol; (S,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (S,S)-ethambutol; 2,2'-(1,2-Ethylenediimino)-di-1-butanol; 2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol
Drug Type Small molecular drug
Therapeutic Class Antitubercular Agents
Company Macleods Pharmaceutical. Ltd
Structure D08QME
Drug Resistance Mutations
Target Name Bacterial Conserved protein (Rv0340)
Gene Name Rv0340
Uniprot ID O33270_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVNSLIPVVSDSLSMSEPI
GAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAVGSVLNQPTPPGPGVTPTD
PRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNHPVVDPHTVEPDHHGYDIHG
[Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: T173M [555460]
Mutation info Frameshift: Minus 24 [555460]
Target Name Bacterial D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (rmlA2)
Gene Name rmlA2
Uniprot ID L7N6A5_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSY
KPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLA
QLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFE
RNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI
APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGC
VIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
[Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: D152N [555460]
Target Name Bacterial dTDP-L-rhamnose synthase (rmlD)
Gene Name rmlD
Uniprot ID RMLD_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVIN
CAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPY
EPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGR
VDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
RVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLP
STRD [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: S257P [555460]
Target Name Bacterial Isoniazid-induced protein (IniA)
Gene Name inia
Uniprot ID INIA_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLT
RARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARL
VLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVG
GLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSR
ATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTAL
WQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVG
DNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEA
KANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAE
TERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA [Mycobacterium tube
rculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: G308R [555460], [556243]
Mutation info Missense: S501W [555460], [556243]
Mutation info Missense: P3A [556243]
Mutation info Missense: R537H [556243]
Target Name Bacterial Isoniazid-induced protein (IniB)
Gene Name iniB
Uniprot ID INIB_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSVAANVVPGLNLGAGDP
MSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAGLASGLGAGFLGQGGLALA
ASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGTGLGAQAGMGFGGGVGLGLGG
QAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGAGVGAGVGGQAGIASQIGVSAGG
GLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSGPLAGVGVGGQAG
AAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGGVGGATAAGVGGAHGDILGHE
GAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGMNPPVTDAPAPQVPARAQPMTT
AAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
[Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: A47T [555460]
Target Name Bacterial Isoniazid-induced protein (IniC)
Gene Name iniC
Uniprot ID INIC_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPLRIALAGTLKAGKSTL
VNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANVPITRRGGLSFDLRRIN
PAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLVPADGVPRVDAVVFLLRT
LNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDAMLSANDVAKRFTRELNQM
GICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNRALLSVDRFVRRDSPLPVDA
GIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERSGLVALRNVIDQQFAQRSDML
KAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFEELRMLSLLPSRATTLNDDEIA
SLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHWRRRAAHPLNDPFTTRACRAAVR
SAEAMVAEFSARR [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: P248A [555460], [556243]
Mutation info Nonsense: Q351 STOP [555460]
Target Name Bacterial Molybdopterin biosynthesis positive regulator (Rv3124)
Gene Name Rv3124
Uniprot ID MOAR1_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MGQRPFSPNHRSGVLNATTAGAVQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQ
VVAADALVQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDR
QQCDLDRFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALT
EDELLVHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDA
YHRLKSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEELTE
SDKDLLPIGLA [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Intergenic: Minus 16 [555460]
Target Name Bacterial Probable arabinosyltransferase C (embA)
Gene Name embA
Uniprot ID EMBA_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MPHDGNERSHRIARLAAVVSGIAGLLLCGIVPLLPVNQTTATIFWPQGSTADGNITQITA
PLVSGAPRALDISIPCSAIATLPANGGLVLSTLPAGGVDTGKAGLFVRANQDTVVVAFRD
SVAAVAARSTIAAGGCSALHIWADTGGAGADFMGIPGGAGTLPPEKKPQVGGIFTDLKVG
AQPGLSARVDIDTRFITTPGALKKAVMLLGVLAVLVAMVGLAALDRLSRGRTLRDWLTRY
RPRVRVGFASRLADAAVIATLLLWHVIGATSSDDGYLLTVARVAPKAGYVANYYRYFGTT
EAPFDWYTSVLAQLAAVSTAGVWMRLPATLAGIACWLIVSRFVLRRLGPGPGGLASNRVA
VFTAGAVFLSAWLPFNNGLRPEPLIALGVLVTWVLVERSIALGRLAPAAVAIIVATLTAT
LAPQGLIALAPLLTGARAIAQRIRRRRATDGLLAPLAVLAAALSLITVVVFRDQTLATVA
ESARIKYKVGPTIAWYQDFLRYYFLTVESNVEGSMSRRFAVLVLLFCLFGVLFVLLRRGR
VAGLASGPAWRLIGTTAVGLLLLTFTPTKWAVQFGAFAGLAGVLGAVTAFTFARIGLHSR
RNLTLYVTALLFVLAWATSGINGWFYVGNYGVPWYDIQPVIASHPVTSMFLTLSILTGLL
AAWYHFRMDYAGHTEVKDNRRNRILASTPLLVVAVIMVAGEVGSMAKAAVFRYPLYTTAK
ANLTALSTGLSSCAMADDVLAEPDPNAGMLQPVPGQAFGPDGPLGGISPVGFKPEGVGED
LKSDPVVSKPGLVNSDASPNKPNAAITDSAGTAGGKGPVGINGSHAALPFGLDPARTPVM
GSYGENNLAATATSAWYQLPPRSPDRPLVVVSAAGAIWSYKEDGDFIYGQSLKLQWGVTG
PDGRIQPLGQVFPIDIGPQPAWRNLRFPLAWAPPEADVARIVAYDPNLSPEQWFAFTPPR
VPVLESLQRLIGSATPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNL
WQSSSTGGPFLFTQALLRTSTIATYLRGDWYRDWGSVEQYHRLVPADQAPDAVVEEGVIT
VPGWGRPGPIRALP [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: A201T [555460], [556238]
Mutation info Missense: A462V [555460], [556238]
Mutation info Missense: D4N [555460], [556238]
Mutation info Missense: D833A [555460], [556238]
Mutation info Missense: G321S [555460], [556238]
Mutation info Missense: G350D [555460], [556238]
Mutation info Missense: P913S [555460], [556238]
Mutation info Missense: G5S [556238]
Mutation info Frameshift: Minus 43 [555460]
Target Name Bacterial Probable arabinosyltransferase C (embB)
Gene Name embB
Uniprot ID EMBB_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MTQCASRRKSTPNRAILGAFASARGTRWVATIAGLIGFVLSVATPLLPVVQTTAMLDWPQ
RGQLGSVTAPLISLTPVDFTATVPCDVVRAMPPAGGVVLGTAPKQGKDANLQALFVVVSA
QRVDVTDRNVVILSVPREQVTSPQCQRIEVTSTHAGTFANFVGLKDPSGAPLRSGFPDPN
LRPQIVGVFTDLTGPAPPGLAVSATIDTRFSTRPTTLKLLAIIGAIVATVVALIALWRLD
QLDGRGSIAQLLLRPFRPASSPGGMRRLIPASWRTFTLTDAVVIFGFLLWHVIGANSSDD
GYILGMARVADHAGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASLWMRLPDLAAGLV
CWLLLSREVLPRLGPAVEASKPAYWAAAMVLLTAWMPFNNGLRPEGIIALGSLVTYVLIE
RSMRYSRLTPAALAVVTAAFTLGVQPTGLIAVAALVAGGRPMLRILVRRHRLVGTLPLVS
PMLAAGTVILTVVFADQTLSTVLEATRVRAKIGPSQAWYTENLRYYYLILPTVDGSLSRR
FGFLITALCLFTAVFIMLRRKRIPSVARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFA
AVGAAMAALTTVLVSPSVLRWSRNRMAFLAALFFLLALCWATTNGWWYVSSYGVPFNSAM
PKIDGITVSTIFFALFAIAAGYAAWLHFAPRGAGEGRLIRALTTAPVPIVAGFMAAVFVA
SMVAGIVRQYPTYSNGWSNVRAFVGGCGLADDVLVEPDTNAGFMKPLDGDSGSWGPLGPL
GGVNPVGFTPNGVPEHTVAEAIVMKPNQPGTDYDWDAPTKLTSPGINGSTVPLPYGLDPA
RVPLAGTYTTGAQQQSTLVSAWYLLPKPDDGHPLVVVTAAGKIAGNSVLHGYTPGQTVVL
EYAMPGPGALVPAGRMVPDDLYGEQPKAWRNLRFARAKMPADAVAVRVVAEDLSLTPEDW
IAVTPPRVPDLRSLQEYVGSTQPVLLDWAVGLAFPCQQPMLHANGIAEIPKFRITPDYSA
KKLDTDTWEDGTNGGLLGITDLLLRAHVMATYLSRDWARDWGSLRKFDTLVDAPPAQLEL
GTATRSGLWSPGKIRIGP [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: G406A [555460], [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: G406D [555460], [555689], [556238]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: M306L [555496], [556208], [556238]
Mutation Prevalence 8 out of 19 isolates
Mutation info Missense: A356V [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A357S [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: D240H [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: D299E [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: D311H [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: E368A [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: E378A [555608], [556238]
Mutation Prevalence 2 out of 16 isolates
Mutation info Missense: I465D [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: L239P [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: M306I [556208], [556238]
Mutation Prevalence 8 out of 19 isolates
Mutation info Missense: M306V [556208], [556238]
Mutation Prevalence 8 out of 19 isolates
Mutation info Missense: N399H [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: P375A [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: P397Q [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: P446H [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: R460C [555689], [556238]
Mutation Prevalence 4 out of 44 isolates
Mutation info Missense: R469P [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: R471P [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: S380R [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: A659T [555549]
Mutation Prevalence 4 out of 20 isolates
Mutation info Missense: M423I [555549]
Mutation Prevalence 4 out of 20 isolates
Mutation info Missense: A221G [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: A225S [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: A271V [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: A281P [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: F281L [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: F287C [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: F287V [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: G294S [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: I293N [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: S272C [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: S272I [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: V128G [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: V227G [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: V282L [555608]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: A310R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A356F [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: A356S [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A357V [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A379D [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A379T [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A388G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A431T [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: D311R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: E368D [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: E368Q [555689]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: E378K [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: E405P [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: F398H [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: F398Y [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G331R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G358V [555689]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: G374V [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: G401S [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G406P [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G448V [555689]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: G459A [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: H312R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: L359I [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: L370R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N296K [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N318H [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N318K [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N318S [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N399D [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N400K [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N400P [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: P371R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: P397T [555689]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: P430L [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: P461S [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: R257W [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: R367P [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: R460L [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: S317T [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: S347I [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: S366P [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: S380D [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: T437A [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V282G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V309G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V360M [555689]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: V369A [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V369L [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V377G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V377M [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V435G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V436G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V452L [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: W395C [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: W395R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: Y315L [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: Y384N [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: D1024N [555460], [556238]
Mutation info Missense: D328G [555460], [556238]
Mutation info Missense: D328Y [555460], [556238]
Mutation info Missense: D959A [555460], [556238]
Mutation info Missense: G406C [555460], [556238]
Mutation info Missense: G406S [555460], [556238]
Mutation info Missense: G745D [555460], [556238]
Mutation info Missense: M1000R [555460], [556238]
Mutation info Missense: Q497K [555460], [556238]
Mutation info Missense: Q497R [555460], [556238]
Mutation info Missense: S297A [555460], [556238]
Mutation info Missense: Y334H [555460], [556238]
Mutation info Missense: M306T [555496], [556238]
Mutation info Missense: Y319C [555582], [556238]
Mutation info Missense: Y319N [555630], [556238]
Mutation info Missense: F330V [556208], [556238]
Mutation info Missense: S347T [555462]
Mutation info Missense: D331Y [555496]
Mutation info Missense: G314A [555496]
Mutation info Missense: Y322C [555496]
Mutation info Missense: R274P [555512]
Mutation info Missense: G314E [555552]
Mutation info Missense: Y333H [555582]
Mutation info Missense: D328V [555595]
Mutation info Missense: S297L [555595]
Mutation info Missense: W332L [555595]
Mutation info Missense: Y319S [555595]
Mutation info Missense: F285L [556208]
Mutation info Missense: E504Q [556238]
Mutation info Missense: L413P [556238]
Mutation info Missense: R507G [556238]
Mutation info Missense: Y333C [556238]
Mutation info Missense: F1012S [556243]
Mutation info Missense: Q998R [556243]
Mutation info Missense: T610K [556243]
Mutation info Missense: R434G [555689]
Mutation info Missense: T630I [556208]
Mutation info Frameshift: Plus 328 [555462]
Target Name Bacterial Probable arabinosyltransferase C (embC)
Gene Name embC
Uniprot ID EMBC_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLN
WPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRG
LLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHP
GAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVAL
TGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTM
ARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVIS
REVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATS
RLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAA
TVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLAL
VLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSL
GALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWS
LTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEV
VSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAG
LSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLP
YNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQW
ATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIAL
TPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEA
NSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTV
TRSGLWSPAPLRRG [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: T270I [555689], [556208], [556238]
Mutation Prevalence 14 out of 44 isolates
Mutation info Missense: A247P [555689], [556238]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: A254G [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: A307T [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G288V [555689], [556238]
Mutation Prevalence 4 out of 44 isolates
Mutation info Missense: G288W [555689], [556238]
Mutation Prevalence 6 out of 44 isolates
Mutation info Missense: G308D [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G325S [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: H285Y [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: I297L [555689], [556238]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: I297T [555689], [556238]
Mutation Prevalence 8 out of 44 isolates
Mutation info Missense: L251R [555608], [556238]
Mutation Prevalence 16 out of 23 isolates in all embB mutations
Mutation info Missense: M300R [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: M310K [555689], [556238]
Mutation Prevalence 4 out of 44 isolates
Mutation info Missense: R302G [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V287F [555689], [556238]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: V303G [555689], [556238]
Mutation Prevalence 6 out of 44 isolates
Mutation info Missense: W326R [555689], [556238]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: Y296H [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: Y296S [555689], [556238]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: Y309N [555689], [556238]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: Y327N [555689], [556238]
Mutation Prevalence 4 out of 44 isolates
Mutation info Missense: A244T [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G272S [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: N394D [555460], [556238]
Mutation info Missense: R738Q [555460], [556238]
Mutation info Missense: V981L [556208], [556238]
Mutation info Missense: G5S [556208]
Mutation info Missense: L502P [556238]
Mutation info Missense: P398S [556238]
Mutation info Missense: Q491R [556238]
Target Name Bacterial Transcriptional regulatory protein (EmbR)
Gene Name embR
Uniprot ID EMBR_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALW
EEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKT
AGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEA
EIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLG
IDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRG
YPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSA
VTLNDGDHIRICDHEFTFQISAGTHGGT [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: C110Y [555689], [556229]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: A176V [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: A187V [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: D223E [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: D53H [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: E200A [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: G240R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: I369T [555689]
Mutation Prevalence 5 out of 44 isolates
Mutation info Missense: L172R [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: L211M [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: L320V [555689]
Mutation Prevalence 2 out of 44 isolates
Mutation info Missense: R186G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: R230W [555689]
Mutation Prevalence 5 out of 44 isolates
Mutation info Missense: R356G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: S188R [555689]
Mutation Prevalence 3 out of 44 isolates
Mutation info Missense: S326N [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: T32P [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V350G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: V7G [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Missense: Q379R [555460], [556229]
Mutation info Missense: H351E [555689]
Mutation info Missense: L292M [555689]
Mutation info Missense: L303E [555689]
Mutation info Missense: I396T [555689]
Mutation Prevalence 1 out of 44 isolates
Mutation info Intergenic: Minus 273 [555460]
Target Name Bacterial Uncharacterized PPE family protein (PPE49)
Gene Name Rv3125c
Uniprot ID PPE49_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MMMMMVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASASSFESVLAALTT
GPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAALAATVHPTAVTANR
VSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGAKSVAATLAPFSLPPVS
LAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQSLVSQLPLQHASMLFLPV
RILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAFKPLGGRELGAGMSAGL
GQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMMLMPMSI
SGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG [Mycobacterium tuberculo
sis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: P54S [555460]
Target Name Bacterial Uncharacterized protein (Rv3126c)
Gene Name Rv3126c
Species Mycobacterium tuberculosis
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: L276R [555460]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 555460Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2000 Feb;44(2):326-36.
Ref 555462Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru. Tuber Lung Dis. 1998;79(2):111-8.
Ref 555496Mutations in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol. Yonsei Med J. 2002 Feb;43(1):59-64.
Ref 555512Surveillance of drug resistant tuberculosis in Hubei, China
Ref 555549Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2004 Nov;48(11):4447-9.
Ref 555552Characterisation of rpsL, rrs and embB mutations associated with streptomycin and ethambutol resistance in Mycobacterium tuberculosis. Res Microbiol. 2004 Dec;155(10):830-4.
Ref 555582The molecular epidemiology of ethambutol-resistant Mycobacterium tuberculosis in Henan Province, China. Jpn J Infect Dis. 2005 Dec;58(6):393-5.
Ref 555595Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2006 May;50(5):1900-2.
Ref 555608Nucleotide polymorphism associated with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis. Curr Microbiol. 2006 Nov;53(5):401-5. Epub 2006 Sep 12.
Ref 555630Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong. J Antimicrob Chemother. 2007 May;59(5):866-73. Epub 2007 Mar 14.
Ref 555689emb nucleotide polymorphisms and the role of embB306 mutations in Mycobacterium tuberculosis resistance to ethambutol. Int J Med Microbiol. 2009 Apr;299(4):269-80. doi: 10.1016/j.ijmm.2008.07.001. Epub 2008 Nov 17.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556238Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Curr Opin Microbiol. 2015 Oct;27:45-50. doi: 10.1016/j.mib.2015.07.004. Epub 2015 Jul 31.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 556208Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations. Antimicrob Agents Chemother. 1997 Aug;41(8):1677-81.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.