Resistance mutation info of drug

Drug General Information
Drug ID D09EGZ
Drug Name Chloroquine Drug Info
Synonyms Amokin; Aralen; Arechin; Arechine; Arequin; Arolen; Arthrochin; Artrichin; Avlochlor; Avloclor; Bemaco; Bemaphate; Bemasulph; Benaquin; Bipiquin; Capquin; Chemochin; Chingamin; Chloraquine; Chlorochin; Chlorochine; Chlorochinum; Chloroin; Chloroquin; Chloroquina; Chloroquinium; Chloroquinum; Chlorquin; Cidanchin; Clorochina; Cloroquina; Cocartrit; Delagil; Dichinalex; Elestol; Gontochin; Heliopar; Imagon; Iroquine; Khingamin; Klorokin; Lapaquin; Malaquin; Malaren; Malarex; Mesylith; Miniquine; Neochin; Nivachine; Pfizerquine; Quinachlor; Quinagamin; Quinagamine; Quinercyl; Quingamine; Quinilon; Quinoscan; Resochen; Resochin; Resoquina; Resoquine; Reumachlor; Reumaquin; Rivoquine; Ronaquine; Roquine; Sanoquin; Silbesan;Siragan; Solprina; Sopaquin; Tanakan; Tanakene; Tresochin; Trochin; Aralen HCl; Chloroquine phosphate; Clorochina [DCIT]; Gontochin phosphate; Nivaquine B; Ipsen 225; RP 3377; SN 6718; ST 21; W 7618;WIN 244; Chloroquine (VAN); Chloroquine Bis-Phosphoric Acid; Chloroquine FNA (TN); Chloroquinum [INN-Latin]; Cloroquina [INN-Spanish]; Dawaquin (TN); RP-3377; Resochin (TN); SN-7618; ST 21 (pharmaceutical); CU-01000012392-2; Chloroquine (USP/INN); Chloroquine [USAN:INN:BAN]; Ro 01-6014/N2; Malaquin (*Diphosphate*); {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine; N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine; N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine; (+)-Chloroquine; (-)-Chloroquine; (R)-(-)-Chloroquine; 3377 RP opalate; 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline; 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
Drug Type Small molecular drug
Therapeutic Class Antimalarials
Company Medreich Sterilab Ltd
Structure D09EGZ
Drug Resistance Mutations
Target Name Parasitic Chloroquine resistance transporter (CRT)
Gene Name CRT
Uniprot ID CRT_PLAFA
Species Plasmodium falciparum
Reference Sequence MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ [Plasmodium falciparum]
Targeted Disease Malaria
Drug Resistance Mutations
Mutation info Missense: K76T [1559265]
References
Ref 536135Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
Ref 540925(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5535).
Ref 1559265pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin.J Infect Dis.2004 Jul 15;190(2):417-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.