Resistance mutation info of drug

Drug General Information
Drug ID D0D0GV
Drug Name Fenhexamid Drug Info
Drug Type Small molecular drug
Structure D0D0GV
Drug Resistance Mutations
Target Name Fungal 3-ketosteroid reductase (erg27)
Gene Name erg27
Uniprot ID K0H656_BOTFU
Species Botrytis cinerea
Reference Sequence MGLPPWETSESQTFALITGANSGLGFAIASRLIDEFLTSSDTPPTKHLILILCTRTPLKT
RFTISRLRAHLRKLADYSEFATSHRAKAKSQGNVYRWQDTVARVHFLGVEVDLCDLKSVY
ALTDRLVNGTVGSPDATTMDGLRLPDGSPGTATYSADVKQDRWALSQKEGSEGELRSWGW
GLSGIRIPRLDVVVLNAGIGGWSGIDWPKAIWTVITDMTEAVTWPTYKLAEIGVITKPQL
SSASSKQAKPSDDEAAQPLLDGESPEEPPLGATFCSNVFGHYVLAHELMPLLSRTASPSA
TTSGRIIWVSSIEAQAQHFDEDDLQGLESRTPYESSKRLTDVLVLSRKLRAAGQASSSWF
DCSDVRVENSKSEEEPAAKLIRPKMYVVQPGIFVSEIMPLNFVLVFIYRLISYLVRWMGS
QWHTIKPYTAAVAPVWVALSPDDVLDNMDGAASKWGSATDASGKERVIRTEVPGWGWEGK
TPKTIDTGERRKGRQRNAEPLTREAREDFEVLGVKCWTEMENLRKEWEGLLKVKK [Bot
rytis cinerea]
Targeted Disease Plant grey mould disease
Drug Resistance Mutations
Mutation info Missense: F412S [1559254]
Mutation info Missense: T63I [1559254]
Target Name Fungal Cytochrome b (cytb)
Gene Name cytb
Uniprot ID Q18ND9_BOTFU
Species Botrytis cinerea
Reference Sequence MRIFKSHPLLKLVNSYMIDSPQPSNLSYLWNFGSLLAVCLVIQIITGVTLAMHYNPSVLE
AFNSVEHIMRDVNNGWLIRYLHSNTASAFFFIVYLHIGRGLYYGSYRAPRTLVWTIGVVI
FILMIVTAFLGYVLPYGQMSLWGATVITNLMSAVPWIGQDIVEFLWGGFSVNNATLNRFF
ALHFVLPFVLAALALMHLIALHDSAGSGNPLGISGNYDRLAFAPYFLFKDLITIFLFIII
LSIFVFFMPNVLGDSDNYIMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMLSAI
LILLAMPFTDLSRSRGIQFRPLSKIAFYIFIANFLILMVLGAKHVESPYIEFGQISTVIY
FAHFLIIVPFISLLENSLVELAVLTKEKPSR [Botrytis cinerea]
Targeted Disease Plant grey mould disease
Drug Resistance Mutations
Mutation info Missense: G143A [1559254]
Target Name Fungal Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb)
Gene Name sdhb
Uniprot ID Q3ZMH5_BOTFU
Species Botrytis cinerea
Reference Sequence MAALRTGARSARAIFAASRPAFRTQMRTMASVDSSVPESPTVSPSRPVESASKTSTVKEP
AADSESLIKTFNIYRWNPDEPTSKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRR
SCREGICGSCAMNIDGVNTLACLCRIPRDAKHETKIYPLPHTYVVKDIVPDLTQFYKQYK
SIKPYLQHTDPAPEGKEYLQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAIL
LQSYRWLADSRDQKKEERKAALDNSMSLYRCHTILNCSRTCPKGLNPGLAIAEIKKEMAF
[Botrytis cinerea]
Targeted Disease Plant grey mould disease
Drug Resistance Mutations
Mutation info Missense: H272R [1559254]
Mutation info Missense: H272Y [1559254]
Target Name Fungal Tubulin beta chain (tubA)
Gene Name tubA
Uniprot ID TBB_BOTFU
Species Botrytis cinerea
Reference Sequence MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYV
PRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVV
RREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVV
EPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCL
RFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMM
AASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRG
LKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDASISEGEEEYEEEVPIEGEE [Botrytis cinerea]
Targeted Disease Plant grey mould disease
Drug Resistance Mutations
Mutation info Missense: E198A [1559254]
Mutation info Missense: F200Y [1559254]
Target Name Fungal Two-component osmosensing histidine-kinase (bos1)
Gene Name bos1
Uniprot ID Q8X1E7_BOTFU
Species Botrytis cinerea
Reference Sequence MEDSTIAHTTAILQTLALSSIDLPLTNVYGNKGIRLPGADTAEKLALERELAALVSRVQR
LEARAITVNNQTLPDTPNELGAPSAFADVLTGAPSRASKSTTSRQQLVNSLLAAREAPTG
GERPPKFTKLSDEELEALREHVDHQSKQLDSQKSELAGVHAQLFEQKQRQEQALNVLEVE
RVAALERELKKHQQANEAFQKALREIGEIVTAVARGDLSKKVQIHSVEMDPEITTFKRVI
NTMMDQLQIFSSEVSRVAREVGTEGILGGQAKISGVDGTWKELTDNVNVMAQNLTDQVRE
IASVTTAVAHGDLTQKIERPAQGEILQLQQTINTMVDQLRTFAAEVTRVARDVGTEGILG
GQAEIEGVQGMWNTLIVNVNAMANNLTTQVRDIAIVTTAVAKGDLTQKVQAECKGEIKQL
KETINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTT
QVREIAKVTTAVARGDLTKKIEVEVQGEIASLKDTINTMVDRLSTFAFEVSKVAREVGTD
GTLGGQAQVDNVEGKWKDLTENVNTMARNLTTQVRGISTVTQAIANGDMSQKIEVAAAGE
ILILKETINNMVDRLSIFSNEVQRVAKDVGVDGKMGGQADVAGIGGRWKEITTDVNTMAN
NLTTQVRAFGDITNAATDGDFTKLITVEASGEMDELKRKINQMVYNLRDSIQRNTLAREA
AEFANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVHNLANSLLTII
DDILDLSKIEANRMIMEEIPYTLRGTVFNALKTLAVKANEKFLDLTYRVDSSVPDHVVGD
SFRLRQVILNLVGNAIKFTEHGEVSLTIQKAEQDHCAPNEYAVEFCVSDTGIGIQADKLN
LIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMRGDVWVKSQYGKGSSFYFTCTVRLAT
SDISFIQKQLKPYQGHNVLFIDKGQTGHGKEIITMLTQLGLVPVVVDSEQHTILLGNGRT
KEKIASTYDVIVVDSIESARKLRSIDEFKYIPIVLLAPVIHVSLKSALDLGITSYMTTPC
LTIDLGNGMIPALENRAAPSLADNTKSFDILLAEDNIVNQRLAVKILEKYHHVVTVVGNG
QEALDAIKEKRYDVILMDVQMPIMGGFEATAKIREYERSLGTQRTPIIALTAHAMLGDRE
KCIQAQMDEYLSKPLKQNHLIQTILKCATLGGALLEKGREVRQSANEESPNSQNGPRGTQ
HPASSPTPAHMRPAIEPRAYTTTGPINHGSAESPSLVTADAEDPLARLLMRAHSS [Bot
rytis cinerea]
Targeted Disease Plant grey mould disease
Drug Resistance Mutations
Mutation info Missense: I365N [1559254]
Mutation info Missense: I365S [1559254]
References
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 1559254Independent Emergence of Resistance to Seven Chemical Classes of Fungicides in Botrytis cinerea.Phytopathology.2015 Apr;105(4):424-32.

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