Resistance mutation info of drug

Drug General Information
Drug ID D0P0HB
Drug Name Ethionamide Drug Info
Synonyms Aethionamidum; Aetina; Aetiva; Amidazin; Amidazine; Atina; Ethatyl; Ethimide; Ethina; Ethinamide; Ethionamidum; Ethioniamide; Ethylisothiamide; Ethyonomide; Etimid; Etiocidan; Etionamid; Etionamida; Etionamide; Etioniamid; Etionid; Etionizin; Etionizina; Etionizine; Fatoliamid; Iridocin; Iridozin; Isothin; Isotiamida; Itiocide; Nicotion; Nisotin; Nizotin; Rigenicid; Sertinon; Teberus; Thianid; Thianide; Thioamide; Thiomid; Thioniden; Tianid; Tiomid; Trecator; Trekator; Trescatyl; Trescazide; Tubenamide; Tubermin; Tuberoid; Tuberoson; Ethionamid prothionamid; Etionamide [DCIT]; Iridocin Bayer; Trecator SC; Wyeth Brand of Ethionamide; Bayer 5312; Bayer5312; E0695; TH 1314; Alpha-Ethylisonicotinic acid thioamide; Alpha-Ethylisonicotinoylthioamide; Alpha-Ethylisothionicotinamide; Alpha-Ethylthioisonicotinamide; Alpha-ethylt hioisonicotinamide; Ethina (VAN); Ethionamidum [INN-Latin]; Etionamida [INN-Spanish]; Tio-Mid; Trecator-SC; Alpha-Ethyl-thioisonicotinamide; Trecator-SC (TN); Ethionamide (JP15/USP/INN); Ethionamide [USAN:INN:BAN:JAN]; 2-ETHYL-4-PYRIDINECARBOTHIOAMIDE; 2-Ethyl-4-thioamidylpyridine; 2-Ethyl-4-thiocarbamoylpyridine; 2-Ethyl-thioisonicotinamide; 2-Ethylisonicotinic acid thioamide; 2-Ethylisonicotinic thioamide; 2-Ethylisonicotinothioamide; 2-Ethylisonicotinoylthioamide; 2-Ethylisothionicotinamide; 2-Ethylthioisonicotinamide; 2-e thylisothionicotinamide; 2-ethyl-4-aminothiocarbonylpyridine; 2-ethylisonicotinic acid thiomide; 2-ethylpyridine-4-carbothioamide; 2-ethylthioisonicotinamide, Trecator SC, Amidazine, Ethionamide; 3-Ethylisothionicotinamide
Drug Type Small molecular drug
Therapeutic Class Antituberculosis Agents
Structure D0P0HB
Drug Resistance Mutations
Target Name Bacterial Enoyl-[acyl-carrier-protein] reductase [NADH] (Inha) Target Info
Gene Name inhA
Uniprot ID INHA_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: I95P [556163]
Mutation Prevalence 7 out of 14 isolates
Mutation info Missense: S94A [555471]
Target Name Bacterial Prodrug activator (EtaA)
Gene Name ethA
Uniprot ID ETHA_MYCTU
Species Mycobacterium tuberculosis
Reference Sequence MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMY
TLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHI
QSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVV
IGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRW
KNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGD
LFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQ
VDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVE
RPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRF
AKRPAPVGV [Mycobacterium tuberculosis]
Targeted Disease Tuberculosis
Drug Resistance Mutations
Mutation info Missense: A381P [555478], [556238]
Mutation info Missense: D58A [555478], [556238]
Mutation info Missense: G43C [555478], [556238]
Mutation info Missense: P51L [555478], [556238]
Mutation info Missense: T186K [555478], [556238]
Mutation info Missense: T342K [555478], [556238]
Mutation info Missense: E223K [555529], [556238]
Mutation info Missense: G385D [555529], [556238]
Mutation info Missense: G413D [555529], [556238]
Mutation info Missense: G43S [555529], [556238]
Mutation info Missense: I338S [555529], [556238]
Mutation info Missense: R463S [555529], [556238]
Mutation info Missense: T392A [555529], [556238]
Mutation info Missense: Y84D [555478]
Mutation info Missense: D55A [555529]
Mutation info Nonsense: Q246 STOP [555529]
Mutation info Frameshift: Plus 22 [555478]
Mutation info Frameshift: Plus 270 [555478]
Mutation info Frameshift: Plus 113 [555529]
Mutation info Frameshift: Plus 234 [555529]
Mutation info Frameshift: Plus 256 [555529]
Mutation info Frameshift: Plus 37 [555529]
Mutation info Frameshift: Plus 430 [555529]
Mutation info Frameshift: Plus 441 [555529]
References
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 555471Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis. 2000 May;4(5):441-7.
Ref 555478Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9677-82.
Ref 555529ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2003 Dec;47(12):3799-805.
Ref 556238Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Curr Opin Microbiol. 2015 Oct;27:45-50. doi: 10.1016/j.mib.2015.07.004. Epub 2015 Jul 31.
Ref 556163New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet. 1995 Aug 19;346(8973):502-3.

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