Resistance mutation info of drug

Drug General Information
Drug ID D0S5VU
Drug Name Herbicide amitrole Drug Info
Drug Resistance Mutations
Target Name Bacterial Glutamine--fructose-6-phosphate aminotransferase (glmS)
Gene Name glmS
Uniprot ID GLMS_SYNY3
Species Synechocystis sp
Reference Sequence MCGIVGYIGTQTAVNILIEGLERLEYRGYDSAGIATVTEGKIESVRAKGKLFNLKEKLEN
HSNFSRLGIGHTRWATHGKPEEHNAHPHLDNQQRIAVVQNGIIENYQTLRDQLKEKGYQF
YSETDTEVIPILIADILKDLPSDDPDEALLEAIGKAVHQLEGAFAIAVLDAHCPEQLIVA
RQQAPLILGFGQGEFFCASDVTALVHHTTTVLSLENGEIARLTPLGVEVYDFNLKRVRKL
PRTLDWSATTVEKQGFRHFMLKEIYEQPAVVRTCLATYLNEQWRAADHPSHSPVFLGLDP
QLTKNLQHIQVLACGTSWHAGLVGKYLLEQLAGIPTTVHYASEFRYAAPPLTPHTLTIGV
TQSGETADTLAALEMEKQRRLTLEDDYKPLILGITNRPESTLATMVNEIINTHAGIEIGV
AATKTFVAQVLAFYFLALDIAFQRHSLSLEAIEHIMVGLRQLPAQIETILEQQGSAIEAL
AHEFAETQDFIFLGRGINFPIALEGALKLKEISYIHAEGYPAGEMKHGPIALLDAKVPVV
AIAMPGSVHDKVISNAQEAKARDARLIGVTPMDDSQARSVFDDLLLVPHVEEMLSPIVAV
IPLQLLSYHIAARRGLDVDQPRNLAKSVTVE [Synechocystis sp]
Targeted Disease Bacterial infection
Drug Resistance Mutations
Mutation info Missense: V250L [1559222]
References
Ref 1572605The ChEMBL database in 2017.
Ref 1559222[Mutation in the glmS gene responsible for the cell wall synthesis increases resistance to the herbicide amitrole in the cyanobacterium Synechocystis sp.PCC6803].Genetika.2000 Oct;36(10):1406-9.

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