Drug General Information
Drug ID D0U4IV
Drug Name Elfamycin Drug Info
Drug Resistance Mutations
Target Name Bacterial Elongation factor Tu (EF-Tu) Target Info
Gene Name EF-Tu
Uniprot ID EFTU_PEPD6
Species Peptoclostridium difficile
Reference Sequence MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGEAVDFANIDKAPEERER
GITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSATDGPMPQTREH
ILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLTEYDFPGDDTPIVRGSALMAL
EDPKSEWGDKIVELFEQIDEYIPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLK
VQDEVELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTG
SVKAHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNV
TMEVDLINSIVVEEGLRFSIREGGRTVASGVVATIIE [Peptoclostridium diff
icile]
Targeted Disease Enterocolitis Due To Clostridium Difficile
Drug Resistance Mutations
Mutation info Missense: G261E [556229]
References
Ref 1572605The ChEMBL database in 2017.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.

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