Resistance mutation info of drug

Drug General Information
Drug ID D0V3YT
Drug Name Boceprevir Drug Info
Drug Type Small molecular drug
Structure D0V3YT
Drug Resistance Mutations
Target Name HCV Serine protease (NS3)
Gene Name NS3
Uniprot ID POLG_HCVJA(1027-1657)
Species Hepatitis C virus genotype 1b
Reference Sequence APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAG
SKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVVPVRRRG
DSRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESMETTMR
SPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAHGIEPNIRTGVRTITTGGPITYSTYCKFLADGGCSGGAYDIIICDECHSTDSTTI
LGIGTVLDQAETAGARLVVLATATPPGSITVPHPNIEEVALSNTGEIPFYGKAIPIEAIK
GGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRAQRRGRTGRGRSGIYRFVTPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLT
HIDAHFLSQTKQAGDNLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY
RLGAVQNEVTLTHPITKYIMACMSADLEVVT [Hepatitis C virus genotype
1b]
Targeted Disease HCV infection
Drug Resistance Mutations
Mutation info Missense: A156S [555585]
Mutation Prevalence 31% of the patiens
Level of Resistance Confer 24 fold resistance
Mutation info Missense: A156T [555585]
Mutation Prevalence 12% of the patiens
Level of Resistance Confer 128 fold resistance
Mutation info Missense: T54A [555585]
Mutation Prevalence 31% of the patiens
Level of Resistance Confer 6.7 fold resistance
Mutation info Missense: V170A [555585]
Mutation Prevalence 25% of the patients
Level of Resistance Confer 19 fold resistance
Mutation info Missense: F43S [555585]
Level of Resistance Confer 3.5 fold resistance
Mutation info Missense: R155K [555585]
Level of Resistance Confer 3.6 fold resistance
Mutation info Missense: V36M [555585]
Level of Resistance Confer 2.9 fold resistance
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 542802(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7876).
Ref 555585Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034. Antiviral Res. 2006 Jun;70(2):28-38. Epub 2006 Jan 13.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.