Drug General Information
Drug ID D0Z0KH
Drug Name Azole Drug Info
Drug Type Small molecular drug
Structure D0Z0KH
Drug Resistance Mutations
Target Name Fungal Delta(7)-sterol 5(6)-desaturase (ERG3)
Gene Name ERG3
Uniprot ID A0A1L2BH72_CANPA
Species Candida parapsilosis
Reference Sequence MDIVLEVCDYYLFDRLYAAALPKGGKVDQFIQNSPVFQQVSSKISQFLPSSSCSGCSDTV
DNALFGNTTASSTFSNALNFQFNATSVNVANLPSYLWSKVMSLQNKSEIYRLKPTFLPAG
DYFSSSILARSNLLRESLTILVITTIFGWLLYLIVAYLSYVFVFDRRIFNHPRYLKNQMW
LEIERAMTAIPVMVALTNPFFLLELKGFSRLYFDINECTGGWKFVFLQIPMFILFTDCLI
YCIHRWLHWPSVYKRLHKPHHKWIVCTPFASHAFHPVDGWAQSLPYHLYPLLFPLHKVLY
LGLFTFVNFWTVMIHDGNYMSNDPVVNGTACHTVHHLYFNYNYGQFTTLWDRIGRSYRRP
DDSFFIKETTAEKEKQEWKKQVTQMEEIRNELEGKVDDREYAEES [Candida parap
silosis]
Targeted Disease Candidiasis
Drug Resistance Mutations
Mutation info Missense: R135I [1559253]
References
Ref 1572605The ChEMBL database in 2017.
Ref 1559253Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance.Clin Microbiol Infect.2017 Aug;23(8):575.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.