Resistance mutation info of target
| Target General Information | |||||||||||||||||||||||
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| Target ID | T05152 | ||||||||||||||||||||||
| Target Name | HCV RNA-directed RNA polymerase (NS5B) | Target Info | |||||||||||||||||||||
| Gene Name | NS5B | ||||||||||||||||||||||
| Species | Hepatitis C virus genotype 1b | ||||||||||||||||||||||
| Uniprot ID | POLG_HCVJA(2420-3010) | ||||||||||||||||||||||
| Sequence | SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVL DDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS TLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIY QCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLW ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG EINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIP AASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR [Hepatit is C virus genotype 1b] |
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| Drug Resistance Mutation and Corresponding Drugs | |||||||||||||||||||||||
| Mutation Info | Missense: F415Y | ||||||||||||||||||||||
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| Mutation Info | Missense: S282T | ||||||||||||||||||||||
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| Reference | |||||||||||||||||||||||
| REF 1 | Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-nae patients. Hepatology. 2008 Dec;48(6):1769-78. doi: 10.1002/hep.22549. | ||||||||||||||||||||||
| REF 2 | Lam, A.M. et al. Selection and characterization of heaptitis C virus replicons using combinations of NS3 protease and NS5B non-nucleoside inhibitors or combination of NS5B nucleotide inhibitors. . in International HIV & Hepatitis Virus Drug Resistance Workshop, Vol. 15 Supplement 2 A28 (Dubrovnik, Croatia, 2010). | ||||||||||||||||||||||
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