Resistance mutation info of target

Target General Information
Target ID T17345
Target Name Bacterial Dihydrofolate reductase (DHFR) Target Info
Gene Name DHFR
Species Streptococcus pneumoniae
Uniprot ID DYR_STRPN
Sequence MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPK
RETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTH
IHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV [Streptococ
cus pneumoniae]
Drug Resistance Mutation and Corresponding Drugs
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Mutation Info Missense: V100L
Drugs
Drug Name Trimethoprim Drug Info [555739]
Targeted Disease Bacterial infection
Reference
Ref 555739Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae. Biochemistry. 2010 Jan 12;49(1):195-206. doi: 10.1021/bi901614m.

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