Resistance mutation info of target

Target General Information
Target ID T31595
Target Name Influenza Neuraminidase (NA) Target Info
Gene Name NA
Species Influenza A viruses H1N1
Uniprot ID C3W5Y1_9INFA
Sequence MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCNQSVITYENNT
WVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREP
FISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWS
ASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFT
VMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN
RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIG
RTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRP
CFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK [Influenza
A viruses H1N1]
Drug Resistance Mutation and Corresponding Drugs
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 467472(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4128).
Ref 537115Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Mutation Info Missense: E119G
Drugs
Drug Name Zanamivir Drug Info [555972]
Targeted Disease Influenza virus infection
Drug Name Oseltamivir Drug Info [555972]
Targeted Disease Influenza virus infection
Drug Name Peramivir Drug Info [555972]
Targeted Disease Influenza virus infection
Mutation Info Missense: H275Y
Drugs
Drug Name Amantadine Drug Info [556158]
Targeted Disease Influenza virus infection
Drug Name Oseltamivir Drug Info [556158]
Targeted Disease Influenza virus infection
Mutation Info Missense: R118P
Drugs
Drug Name Zanamivir Drug Info [556075]
Targeted Disease Influenza virus infection
Mutation Info Missense: R292K
Drugs
Drug Name Zanamivir Drug Info [556075]
Targeted Disease Influenza virus infection
Mutation Info Missense: R292W
Drugs
Drug Name Zanamivir Drug Info [556075]
Targeted Disease Influenza virus infection
Reference
Ref 555972Insights into susceptibility of antiviral drugs against the E119G mutant of 2009 influenza A (H1N1) neuraminidase by molecular dynamics simulations and free energy calculations. Antiviral Res. 2013 Nov;100(2):356-64. doi: 10.1016/j.antiviral.2013.09.006. Epub 2013 Sep 19.
Ref 556075Computational assay of Zanamivir binding affinity with original and mutant influenza neuraminidase 9 using molecular docking. J Theor Biol. 2015 Nov 21;385:31-9. doi: 10.1016/j.jtbi.2015.08.019. Epub 2015 Sep 1.
Ref 556158Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. Eur J Med Chem. 2017 Jul 28;135:70-76. doi: 10.1016/j.ejmech.2017.04.038. Epub 2017 Apr 20.

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