Resistance mutation info of target
| Target General Information | ||||||||||||||||||
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| Target ID | T31595 | |||||||||||||||||
| Target Name | Influenza Neuraminidase (NA) | Target Info | ||||||||||||||||
| Gene Name | NA | |||||||||||||||||
| Species | Influenza A viruses H1N1 | |||||||||||||||||
| Uniprot ID | C3W5Y1_9INFA | |||||||||||||||||
| Sequence | MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCNQSVITYENNT WVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREP FISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWS ASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFT VMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIG RTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRP CFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK [Influenza A viruses H1N1] |
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| Drug Resistance Mutation and Corresponding Drugs | ||||||||||||||||||
| Mutation Info | Missense: E119G | |||||||||||||||||
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| Mutation Info | Missense: H275Y | |||||||||||||||||
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| Mutation Info | Missense: R118P | |||||||||||||||||
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| Mutation Info | Missense: R292K | |||||||||||||||||
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| Mutation Info | Missense: R292W | |||||||||||||||||
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| Reference | ||||||||||||||||||
| REF 1 | Insights into susceptibility of antiviral drugs against the E119G mutant of 2009 influenza A (H1N1) neuraminidase by molecular dynamics simulations and free energy calculations. Antiviral Res. 2013 Nov;100(2):356-64. doi: 10.1016/j.antiviral.2013.09.006. Epub 2013 Sep 19. | |||||||||||||||||
| REF 2 | Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. Eur J Med Chem. 2017 Jul 28;135:70-76. doi: 10.1016/j.ejmech.2017.04.038. Epub 2017 Apr 20. | |||||||||||||||||
| REF 3 | Computational assay of Zanamivir binding affinity with original and mutant influenza neuraminidase 9 using molecular docking. J Theor Biol. 2015 Nov 21;385:31-9. doi: 10.1016/j.jtbi.2015.08.019. Epub 2015 Sep 1. | |||||||||||||||||
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