| Target General Information |
|---|
| Target ID |
T72657 |
| Target Name |
Bacterial 30S ribosomal protein S12 (rpsL) |
Target Info
|
| Gene Name |
rpsL |
| Species |
Mycobacterium tuberculosis |
| Uniprot ID |
RS12_MYCTU |
| Sequence |
MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQ
VEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAK
KEKG [Mycobacterium tuberculosis] |
| Drug Resistance Mutation and Corresponding Drugs |
|---|
| Mutation Info |
Missense: G84V |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K43R |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[2],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K43T |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[4]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
5 out of 15 isolates |
|
| Mutation Info |
Missense: K51N |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: K88M |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[5]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
10 out of 17 isolates |
|
| Mutation Info |
Missense: K88Q |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[6],
[3]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
9 out of 139 isolates |
|
| Mutation Info |
Missense: K88R |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[4],
[3]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
2 out of 15 isolates |
|
| Mutation Info |
Missense: K88T |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[5]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
10 out of 17 isolates |
|
| Mutation Info |
Missense: R86P |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[7]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: R86W |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: R9H |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[6]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 139 isolates |
|
| Mutation Info |
Missense: T40I |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1],
[3]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: T41S |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V52G |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V87L |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[1]
|
| Targeted Disease |
Tuberculosis |
|
| Mutation Info |
Missense: V93M |
| Drugs |
| Drug Name |
Streptomycin |
Drug Info |
[6]
|
| Targeted Disease |
Tuberculosis |
| Mutation Prevalence |
1 out of 139 isolates |
|
| Reference |
|---|
| REF 1 | Molecular characterisation of streptomycin-resistant Mycobacterium tuberculosis strains isolated in Poland. Int J Tuberc Lung Dis. 2004 Aug;8(8):1032-5. |
|---|
| REF 2 | The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis. Mol Microbiol. 1993 Nov;10(3):521-7. |
|---|
| REF 3 | CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26. |
|---|
| REF 4 | Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot. Mol Microbiol. 1993 Sep;9(6):1239-46. |
|---|
| REF 5 | Characterization of the rpsL and rrs genes of streptomycin-resistant clinical isolates of Mycobacterium tuberculosis in Japan. J Appl Microbiol. 1997 Nov;83(5):634-40. |
|---|
| REF 6 | Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities. Antimicrob Agents Chemother. 1996 Apr;40(4):1024-6. |
|---|
| REF 7 | Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. Mol Microbiol. 2007 Feb;63(4):1096-106. |
|---|
