Resistance mutation info of target

Target General Information
Target ID T79068
Target Name Bacterial Enoyl-[acyl-carrier-protein] reductase [NADH] (Inha) Target Info
Gene Name inhA
Species Mycobacterium tuberculosis
Uniprot ID INHA_MYCTU
Sequence MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL [Mycobacterium tuberculosis]
Drug Resistance Mutation and Corresponding Drugs
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Mutation Info Missense: E217D
Drugs
Drug Name Isoniazid Drug Info [555711]
Targeted Disease Tuberculosis
Mutation Prevalence 1 out of 28 isolates
Mutation Info Missense: I16T
Drugs
Drug Name Isoniazid Drug Info [556219], [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: I194T
Drugs
Drug Name Isoniazid Drug Info [555587], [556243]
Targeted Disease Tuberculosis
Mutation Prevalence 52 out of 102 isolates
Mutation Info Missense: I21T
Drugs
Drug Name Isoniazid Drug Info [555529], [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: I21V
Drugs
Drug Name Isoniazid Drug Info [555529], [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: I47T
Drugs
Drug Name Isoniazid Drug Info [556219], [556243]
Targeted Disease Tuberculosis
Mutation Info Missense: I95P
Drugs
Drug Name Isoniazid Drug Info [556163], [556243]
Targeted Disease Tuberculosis
Mutation Prevalence 7 out of 14 isolates
Drug Name Ethionamide Drug Info [556163]
Targeted Disease Tuberculosis
Mutation Prevalence 7 out of 14 isolates
Mutation Info Missense: I95T
Drugs
Drug Name Isoniazid Drug Info [555461]
Targeted Disease Tuberculosis
Mutation Info Missense: K8N
Drugs
Drug Name Isoniazid Drug Info [555748]
Targeted Disease Tuberculosis
Mutation Info Missense: R202G
Drugs
Drug Name Isoniazid Drug Info [555711]
Targeted Disease Tuberculosis
Mutation Prevalence 1 out of 28 isolates
Mutation Info Missense: S94A
Drugs
Drug Name Isoniazid Drug Info [555471], [556243]
Targeted Disease Tuberculosis
Drug Name Ethionamide Drug Info [555471]
Targeted Disease Tuberculosis
Mutation Info Missense: S94L
Drugs
Drug Name Isoniazid Drug Info [555604]
Targeted Disease Tuberculosis
Mutation Info Missense: V78A
Drugs
Drug Name Isoniazid Drug Info [556219], [556243]
Targeted Disease Tuberculosis
Reference
Ref 555461Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998;79(1):3-29.
Ref 555471Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis. 2000 May;4(5):441-7.
Ref 555529ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2003 Dec;47(12):3799-805.
Ref 555587Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA. Antimicrob Agents Chemother. 2006 Mar;50(3):1075-8.
Ref 555604Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med. 2006 Sep;12(9):1027-9. Epub 2006 Aug 13.
Ref 555711Performance assessment of the GenoType MTBDRplus test and DNA sequencing in detection of multidrug-resistant Mycobacterium tuberculosis. J Clin Microbiol. 2009 Aug;47(8):2520-4. doi: 10.1128/JCM.02499-08. Epub 2009 Jun 3.
Ref 555748http://www.ncbi.nlm.nih.gov/pubmed/2007582629
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 556163New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet. 1995 Aug 19;346(8973):502-3.
Ref 556219Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. J Infect Dis. 1998 Sep;178(3):769-75.

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