Target Information

Target General Infomation
Target ID
T37046
Former ID
TTDS00494
Target Name
Biliverdin reductase A
Gene Name
BLVRA
Synonyms
BLVR; BVR; BVR A; Biliverdin-IX alpha-reductase; BLVRA
Target Type
Successful
Disease Primary biliary cirrhosis [ICD9: 571.6; ICD10: K74.3]
Function
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
BioChemical Class
Oxidoreductases acting on CH-CH group of donors
UniProt ID
P53004
EC Number
EC 1.3.1.24
Sequence
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
Drugs and Mode of Action
Drug(s) Ursodeoxycholic acid Drug Info Approved Primary biliary cirrhosis [542111], [550774]
Inhibitor Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Activator Ursodeoxycholic acid Drug Info [536467], [536818]
Pathways
BioCyc Pathway Heme degradation
KEGG Pathway Porphyrin and chlorophyll metabolism
PathWhiz Pathway Porphyrin Metabolism
References
Ref 542111(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7104).
Ref 550774Drug information of Ursodeoxycholic acid, 2008. eduDrugs.
Ref 536467Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7.
Ref 536818Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):327-36. Epub 2008 Jul 23.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.