Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T78915
|
||||
Former ID |
TTDI01969
|
||||
Target Name |
Tryptophan 5-hydroxylase-1
|
||||
Gene Name |
TPH1
|
||||
Synonyms |
TPH1
|
||||
Target Type |
Clinical Trial
|
||||
Disease | Psychotic disorders [ICD9: 290-299; ICD10: F20-F29] | ||||
BioChemical Class |
Oxidoreductases acting on paired donors
|
||||
UniProt ID | |||||
EC Number |
EC 1.14.16.4
|
||||
Sequence |
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA MNELQHDLDVVSDALAKVSRKPSI |
||||
Drugs and Mode of Action | |||||
Pathways | |||||
BioCyc Pathway | Superpathway of tryptophan utilization | ||||
Serotonin and melatonin biosynthesis | |||||
KEGG Pathway | Tryptophan metabolism | ||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
PANTHER Pathway | 5-Hydroxytryptamine biosynthesis | ||||
PathWhiz Pathway | Tryptophan Metabolism | ||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Biogenic Amine Synthesis | |||||
Tryptophan metabolism | |||||
Metabolism of amino acids and derivatives | |||||
References | |||||
Ref 526166 | Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.