Target Information

Target General Infomation
Target ID
T53588
Former ID
TTDI02066
Target Name
Escherichia coli NADH-dependent enoyl-ACP reductase
Gene Name
fabI
Synonyms
ENR; Enoyl[acylcarrierprotein] reductase [NADH] FabI; NADHdependent enoylACP reductase; fabI
Target Type
Research
Disease Methicillin-resistant staphylococcus aureus infection [ICD10: B95.62]
Function
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.
BioChemical Class
Short-chain dehydrogenases reductases
UniProt ID
P0AEK4
EC Number
EC=1.3.1.9
Sequence
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIV
LQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDIS
SYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPE
GVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGI
SGEVVHVDGGFSIAAMNELELK
Drugs and Mode of Action
Drug(s) MUT-056399 Drug Info Preclinical Methicillin-resistant staphylococcus aureus infection [548048]
Modulator MUT-056399 Drug Info [531594]
References
Ref 548048Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021501)
Ref 531594The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.